Publication Name	World Journal of Nephrology
Manuscript ID	48822
Country	Netherlands

Category	Urology & Nephrology
Manuscript Type	Case Control Study
Article Title	Complement activation and long-term graft function in ABO-incompatible kidney transplantation
Manuscript Source	Unsolicited Manuscript
All Author List	Marit S van Sandwijk, Astrid Klooster, Ineke JM ten Berge, Arjan Diepstra, Sandrine Florquin, Joris J Hoelbeek, Frederike J Bemelman and Jan-Stephan Sanders
Funding Agency and Grant Number
Corresponding Author	Marit S van Sandwijk, MD, Staff Physician, Department of Nephrology, Amsterdam University Medical Centers, location AMC, Meibergdreef 9, Amsterdam NL-1105 AZ, Netherlands. m.s.vansandwijk@amsterdamumc.nl
Key Words	ABO-incompatible; Kidney transplantation; Complement; Graft function; Rejection;
Core Tip	This retrospective case-control study was designed to unravel the relationship between complement activation, pre-transplant anti-ABO antibodies, and renal graft function. In this study, the slope of kidney function during a five-year follow up was not significantly different compared to matched ABO-compatible transplant recipients, but ABO-incompatible kidney transplant recipients did have a lower kidney function at three months, due to a high rate of early T-cell mediated rejection. Based on several complement staining results, we argue that this may be due to co-stimulation of T-cell activation by ongoing complement activation by anti-ABO antibodies.
Citation	van Sandwijk MS, Klooster A, ten Berge IJM, Diepstra A, Florquin S, Hoelbeek JJ, Bemelman FJ, Sanders JS. Complement activation and long-term graft function in ABO-incompatible kidney transplantation. World J Nephrol 2019; 8(6): 95-108

Received	2019-05-22 01:21
Peer-Review Started	2019-05-23 11:22
To Make the First Decision	2019-08-06 01:28
Return for Revision	2019-08-06 05:08
Revised	2019-08-29 14:13
Second Decision	2019-10-18 08:10
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-10-18 23:08
Articles in Press	2019-10-18 23:08
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2019-10-25 03:31

ISSN	2220-6124 (online)
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