Publication Name	World Journal of Gastroenterology
Manuscript ID	49198
Country	Brazil

Category	Gastroenterology & Hepatology
Manuscript Type	Prospective Study
Article Title	Long-term outcomes of hepatocellular carcinoma that underwent chemoembolization for bridging or downstaging
Manuscript Source	Unsolicited Manuscript
All Author List	Breno Boueri Affonso, Francisco Leonardo Galastri, Joaquim Mauricio da Motta Leal Filho, Felipe Nasser, Priscila Mina Falsarella, Rafael Noronha Cavalcante, Marcio Dias de Almeida, Guilherme Eduardo Gonçalves Felga, Leonardo Guedes Moreira Valle and Nelson Wolosker
Funding Agency and Grant Number
Corresponding Author	Breno Boueri Affonso, PhD, Medical Assistant, Research Scientist, Staff Physician, Surgeon, Teacher, Department of Interventional Radiology, Hospital Israelita Albert Einstein, Av. Albert Einstein, 627/701, São Paulo 05651-901, São Paulo, Brazil. breno.affonso@einstein.br
Key Words	Hepatocellular carcinoma; Down-staging; Liver transplantation; Local regional therapy; Bridging;
Core Tip	The great finding of this work was that through a homogeneous technique of hepatic chemoembolization with drug eluting beads, it was possible to perform the procedures controlling the drug delivery and end point. In conclusion, as far as the degree of tumor necrosis as well as in relation to survival, there was no difference between the group within the Milan criteria (bridging) and the group outside the criteria (downstaging). Therefore, it is worth investing in the treatment of patients out of the Milan criteria so that they have a survival with the same expectations of the patients in criterion.
Citation	Affonso BB, Galastri FL, da Motta Leal Filho JM, Nasser F, Falsarella PM, Cavalcante RN, de Almeida MD, Felga GEG, Valle LGM, Wolosker N. Long-term outcomes of hepatocellular carcinoma that underwent chemoembolization for bridging or downstaging. World J Gastroenterol 2019; 25(37): 5687-5701

Received	2019-06-01 09:32
Peer-Review Started	2019-06-03 08:21
To Make the First Decision	2019-07-22 03:46
Return for Revision	2019-07-24 03:02
Revised	2019-08-30 20:29
Second Decision	2019-09-10 10:41
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-09-10 21:06
Articles in Press	2019-09-10 21:06
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2019-09-25 09:28

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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