Publication Name	World Journal of Gastroenterology
Manuscript ID	49313
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	LncRNA-ATB promotes autophagy by activating yes-associated protein and inducing autophagy-related protein 5 expression in hepatocellular carcinoma
Manuscript Source	Unsolicited Manuscript
All Author List	Chuan-Zhuo Wang, Guang-Xin Yan, De-Shuo Dong, He Xin and Zhao-Yu Liu
Funding Agency and Grant Number
Corresponding Author	Zhao-Yu Liu, MD, Academic Research, Adjunct Professor, Chairman, Department of Radiology, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Heping District, Shenyang City, Liaoning Province, China: 110004, Shenyang 110004, Liaoning, China. liuzy_sj@126.com
Key Words	LncRNA-ATB; Autophagy; Yes-associated protein; Autophagy-related protein 5; Hepatocellular carcinoma;
Core Tip	In the present study, we identified relationship between lncRNA-activated by transforming growth factor beta (lncRNA-ATB) and autophagy in hepatocellular carcinoma (HCC). We demonstrate that lncRNA-ATB promotes autophagic flux in HCC cells. To explore the mechanism, we found that lncRNA-ATB regulates autophagy by activating yes-associated protein and increasing autophagy-related protein 5 expression. Our findings provide a novel link between lncRNA-ATB and autophagy, and suggest that lncRNA-ATB may be a potential therapeutic target in the treatment of HCC.
Citation	Wang CZ, Yan GX, Dong DS, Xin H, Liu ZY, LncRNA-ATB promotes autophagy by activating yes-associated protein and inducing autophagy-related protein 5 expression in hepatocellular carcinoma. World J Gastroenterol 2019; 25(35):5310-5322

Received	2019-05-24 06:06
Peer-Review Started	2019-05-27 06:35
To Make the First Decision	2019-07-22 02:23
Return for Revision	2019-07-23 06:47
Revised	2019-07-30 09:57
Second Decision	2019-08-02 10:21
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-08-07 09:34
Articles in Press	2019-08-07 09:34
Publication Fee Transferred
Edit the Manuscript by Language Editor	2019-08-14 03:05
Typeset the Manuscript	2019-09-18 08:17

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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