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Publication Name World Journal of Gastroenterology
Manuscript ID 49313
Country/Territory China
Category Gastroenterology and Hepatology
Manuscript Type Basic Study
Article Title LncRNA-ATB promotes autophagy by activating yes-associated protein and inducing autophagy-related protein 5 expression in hepatocellular carcinoma
Manuscript Source Unsolicited Manuscript
All Author List Chuan-Zhuo Wang, Guang-Xin Yan, De-Shuo Dong, He Xin and Zhao-Yu Liu
Funding Agency and Grant Number
Corresponding author Zhao-Yu Liu, MD, Academic Research, Adjunct Professor, Chairman, Department of Radiology, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Heping District, Shenyang City, Liaoning Province, China: 110004, Shenyang 110004, Liaoning, China. liuzy_sj@126.com
Keywords LncRNA-ATB; Autophagy; Yes-associated protein; Autophagy-related protein 5; Hepatocellular carcinoma;
Core Tip In the present study, we identified relationship between lncRNA-activated by transforming growth factor beta (lncRNA-ATB) and autophagy in hepatocellular carcinoma (HCC). We demonstrate that lncRNA-ATB promotes autophagic flux in HCC cells. To explore the mechanism, we found that lncRNA-ATB regulates autophagy by activating yes-associated protein and increasing autophagy-related protein 5 expression. Our findings provide a novel link between lncRNA-ATB and autophagy, and suggest that lncRNA-ATB may be a potential therapeutic target in the treatment of HCC.
Citation Wang CZ, Yan GX, Dong DS, Xin H, Liu ZY, LncRNA-ATB promotes autophagy by activating yes-associated protein and inducing autophagy-related protein 5 expression in hepatocellular carcinoma. World J Gastroenterol 2019; 25(35):5310-5322
2019-05-24 06:06
Peer-Review Started
2019-05-27 06:35
To Make the First Decision
2019-07-22 02:23
Return for Revision
2019-07-23 06:47
2019-07-30 09:57
Second Decision
2019-08-02 10:21
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-08-07 09:34
Articles in Press
2019-08-07 09:34
Publication Fee Transferred
Edit the Manuscript by Language Editor
2019-08-14 03:05
Typeset the Manuscript
2019-09-18 08:17
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Assistant Editor Xiang Li
Science Editor Ruo-Yu Ma (Quit in 2020)
Reviewer Code 02942039
Editorial Director Ze-Mao Gong
Journal Chief Editor
Company Chief Editor Lian-Sheng Ma
Language Editor Tian-Qi Wang
Electronic Editor Yu-Jie Ma
Responsible Electronic Editor Yu-Jie Ma
Responsible Science Editor Ze-Mao Gong
Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma
Full Article (PDF) WJG-25-5310.pdf
Manuscript File 49313-Review_Edited.doc
Answering Reviewers 49313-Answering reviewers.pdf
Audio Core Tip 49313-Audio core tip.mp3
Biostatistics Review Certificate 49313-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 49313-Conflict-of-interest statement.pdf
Copyright License Agreement 49313-Copyright license agreement.pdf
Institutional Review Board Approval Form or Document 49313-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 49313-Language certificate.pdf
Peer-review Report 49313-Peer-review(s).pdf
Scientific Misconduct Check 49313-Google-Tang JZ-2.png
Scientific Misconduct Check 49313-Scientific misconduct check.pdf
Scientific Editor Work List 49313-Scientific editor work list.pdf