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Publication Name World Journal of Gastroenterology
Manuscript ID 49445
Country of Manuscript Source Italy
Specialty Gastroenterology and Hepatology
Manuscript type Minireviews
Article Title Optimizing proton pump inhibitors in Helicobacter pylori treatment: Old and new tricks to improve effectiveness
Manuscript Source Invited Manuscript
All Author List Enzo Ierardi, Giuseppe Losurdo, Rosa Federica La Fortezza, Mariabeatrice Principi, Michele Barone and Alfredo Di Leo
Funding Agency and Grant Number
Correspondence To Enzo Ierardi, MD, Academic Fellow, Associate Professor, Doctor, Section of Gastroenterology, Department of Emergency and Organ Transplantation, University of Bari, Piazza Giulio Cesare 11, Bari 70124, Italy. e.ierardi@virgilio.it
Keywords Helicobacter pylori; Proton pump inhibitors; Eradication; Cytochrome P450; Optimization;
Core Tip The most adequate acid suppression by proton pump inhibitors (PPIs) is fundamental to optimize antibiotic therapies for Helicobacter pylori eradication. Herein, we summarize data from literature in order to ascertain the most effective strategies in this topic. Increasing PPI dose showed a real benefit on eradication rate even in the absence of dedicated trials. Second-generation PPIs, as demonstrated in some meta-analyses, may be more effective than old PPI molecules. Finally, vonoprazan, a novel molecule, has shown promising results but, currently, data come from Asian countries, therefore its strong power needs to be confirmed outside this geographic area.
Citation Ierardi E, Losurdo G, La Fortezza RF, Principi M, Barone M, Di Leo A. Optimizing proton pump inhibitors in Helicobacter pylori treatment: Old and new tricks to improve effectiveness. World J Gastroenterol 2019; In press
Received
2019-05-28 01:17
Peer-Review Started
2019-05-28 06:10
To Make the First Decision
2019-07-22 03:33
Return for Revision
2019-07-23 02:24
Revised
2019-07-26 10:54
Second Decision
2019-08-02 10:24
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-08-07 09:31
Articles in Press
2019-08-07 09:31
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Assistant Editor Xiang Li
Science Editor Jia-Ping Yan
Reviewer Code 03008931, and 01557050
Editorial Director Ze-Mao Gong
Journal Chief Editor
Company Chief Editor Lian-Sheng Ma
Language Editor
Electronic Editor
Responsible Electronic Editor
Responsible Science Editor
Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma
Manuscript File 49445-Review.doc
Answering Reviewers 49445-Answering reviewers.pdf
Audio Core Tip 49445-Audio core tip.m4a
Conflict-of-Interest Disclosure Form 49445-Conflict-of-interest statement.pdf
Copyright License Agreement 49445-Copyright license agreement.pdf
Peer-review Report 49445-Peer-review(s).pdf
Scientific Misconduct Check 49445-Scientific misconduct check.pdf
Scientific Editor Work List 49445-Scientific editor work list.pdf