Publication Name	World Journal of Gastroenterology
Manuscript ID	49445
Country	Italy

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Optimizing proton pump inhibitors in Helicobacter pylori treatment: Old and new tricks to improve effectiveness
Manuscript Source	Invited Manuscript
All Author List	Enzo Ierardi, Giuseppe Losurdo, Rosa Federica La Fortezza, Mariabeatrice Principi, Michele Barone and Alfredo Di Leo
Funding Agency and Grant Number
Corresponding Author	Enzo Ierardi, MD, Academic Fellow, Associate Professor, Doctor, Section of Gastroenterology, Department of Emergency and Organ Transplantation, University of Bari, Piazza Giulio Cesare 11, Bari 70124, Italy. e.ierardi@virgilio.it
Key Words	Helicobacter pylori; Proton pump inhibitors; Eradication; Cytochrome P450; Optimization;
Core Tip	The most adequate acid suppression by proton pump inhibitors (PPIs) is fundamental to optimize antibiotic therapies for Helicobacter pylori eradication. Herein, we summarize data from literature in order to ascertain the most effective strategies in this topic. Increasing PPI dose showed a real benefit on eradication rate even in the absence of dedicated trials. Second-generation PPIs, as demonstrated in some meta-analyses, may be more effective than old PPI molecules. Finally, vonoprazan, a novel molecule, has shown promising results but, currently, data come from Asian countries, therefore its strong power needs to be confirmed outside this geographic area.
Citation	Ierardi E, Losurdo G, La Fortezza RF, Principi M, Barone M, Di Leo A. Optimizing proton pump inhibitors in Helicobacter pylori treatment: Old and new tricks to improve effectiveness. World J Gastroenterol 2019; 25(34): 5097-5104

Received	2019-05-28 01:17
Peer-Review Started	2019-05-28 06:10
To Make the First Decision	2019-07-22 03:33
Return for Revision	2019-07-23 02:24
Revised	2019-07-26 10:54
Second Decision	2019-08-02 10:24
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-08-07 09:31
Articles in Press	2019-08-07 09:31
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2019-09-11 08:25

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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