Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	49461
Country	Saudi Arabia

Category	Gastroenterology & Hepatology
Manuscript Type	Systematic Reviews
Article Title	Systematic review of anorectal leiomyosarcoma: Current challenges and recent advances
Manuscript Source	Unsolicited Manuscript
All Author List	Mohammed O Nassif, Razan Habib, Luai Almarzouki and Nora Trabulsi
Funding Agency and Grant Number
Corresponding Author	Mohammed O Nassif, FACS, FRSC, MD, Doctor, Department of General Surgery, King Abdulaziz University, PO Box 80215, Aljamaa St, Jeddah 21589, Saudi Arabia. dr.monassif@gmail.com
Key Words	Leiomyosarcoma; Rectal neoplasms; Anal neoplasms; Gastrointestinal neoplasms; Soft tissue neoplasms;
Core Tip	The current mainstay treatment of anorectal leiomyosarcoma is surgical resection with negative margins. Based on the published case series and reports, sphincter-preserving surgery followed by radiotherapy yields local recurrence rates that are comparable to radical resection. Moreover, neoadjuvant radiation improves local recurrence rates, as compared to adjuvant radiation. Adjuvant chemotherapy significantly improves rates of distant recurrence and overall survival; however, the choice to use chemotherapy in this setting should be determined according to a multidisciplinary team consideration of patient-related factors and treatment toxicity. Since local and distant tumor recurrences are common, even years after resection, post-surgery long-term follow-up is needed.
Citation	Nassif MO, Habib RA, Almarzouki LZ, Trabulsi NH. Systematic review of anorectal leiomyosarcoma: Current challenges and recent advances. World J Gastrointest Surg 2019; 11(8): 334-341

Received	2019-05-29 08:26
Peer-Review Started	2019-06-04 06:24
To Make the First Decision	2019-08-02 06:39
Return for Revision	2019-08-05 02:32
Revised	2019-08-10 19:54
Second Decision	2019-08-13 06:37
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-08-13 08:26
Articles in Press	2019-08-13 08:26
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2019-08-23 01:40

ISSN	1948-9366 (online)
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