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Publication Name World Journal of Gastrointestinal Surgery
Manuscript ID 49461
Country of Manuscript Source Saudi Arabia
Specialty Gastroenterology and Hepatology
Manuscript Type Systematic Review
Article Title Systematic review of anorectal leiomyosarcoma: Current challenges and recent advances
Manuscript Source Unsolicited Manuscript
All Author List Mohammed O Nassif, Razan Habib, Luai Almarzouki and Nora Trabulsi
Funding Agency and Grant Number
Corresponding author Mohammed O Nassif, FACS, FRSC, MD, Doctor, Department of General Surgery, King Abdulaziz University, PO Box 80215, Aljamaa St, Jeddah 21589, Saudi Arabia. dr.monassif@gmail.com
Keywords Leiomyosarcoma; Rectal neoplasms; Anal neoplasms; Gastrointestinal neoplasms; Soft tissue neoplasms;
Core Tip The current mainstay treatment of anorectal leiomyosarcoma is surgical resection with negative margins. Based on the published case series and reports, sphincter-preserving surgery followed by radiotherapy yields local recurrence rates that are comparable to radical resection. Moreover, neoadjuvant radiation improves local recurrence rates, as compared to adjuvant radiation. Adjuvant chemotherapy significantly improves rates of distant recurrence and overall survival; however, the choice to use chemotherapy in this setting should be determined according to a multidisciplinary team consideration of patient-related factors and treatment toxicity. Since local and distant tumor recurrences are common, even years after resection, post-surgery long-term follow-up is needed.
Citation Nassif MO, Habib RA, Almarzouki LZ, Trabulsi NH. Systematic review of anorectal leiomyosarcoma: Current challenges and recent advances. World J Gastrointest Surg 2019; 11(8): 334-341
Received
2019-05-29 08:26
Peer-Review Started
2019-06-04 06:24
To Make the First Decision
2019-08-02 06:39
Return for Revision
2019-08-05 02:32
Revised
2019-08-10 19:54
Second Decision
2019-08-13 06:37
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-08-13 08:26
Articles in Press
2019-08-13 08:26
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2019-08-23 01:40
ISSN 1948-9366 (online)
Open Access This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Assistant Editor Xiang Li
Science Editor Li-Jun Cui (Quit in 2019)
Reviewer Code 01438831
Editorial Director Jin-Lei Wang
Journal Chief Editor
Company Chief Editor Lian-Sheng Ma
Language Editor
Electronic Editor Bao-Xia Zhou (Quit in 2019)
Responsible Electronic Editor Bao-Xia Zhou (Quit in 2019)
Responsible Science Editor Jin-Lei Wang
Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma
Full Article (PDF) WJGS-11-334.pdf
Full Article (Word) WJGS-11-334.docx
Manuscript File 49461-Review.docx
Answering Reviewers 49461-Answering reviewers.pdf
Audio Core Tip 49461-Audio core tip.mp3
Biostatistics Review Certificate 49461-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 49461-Conflict-of-interest statement.pdf
Copyright License Agreement 49461-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate 49461-Language certificate.pdf
Peer-review Report 49461-Peer-review(s).pdf
Scientific Misconduct Check 49461-Scientific misconduct check.pdf
Scientific Editor Work List 49461-Scientific editor work list.pdf