Publication Name	World Journal of Gastroenterology
Manuscript ID	49795
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Zinc-α2-glycoprotein 1 attenuates nonalcoholic fatty liver by negatively regulating tumour necrosis factor-α
Manuscript Source	Unsolicited Manuscript
All Author List	Ting Liu, Xin Luo, Zheng-Hong Li, Jun-Cheng Wu, Sheng-Zheng Luo and Ming-Yi Xu
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81570547 Development Program of China during the 13th Five-year Plan Period 2017ZX10203202003005 National Natural Science Foundation of China 81770597
Corresponding Author	Ming-Yi Xu, MD, Chief Doctor, Professor, Department of Gastroenterology, Shanghai General Hospital, No 100, Haining Rd, Shanghai 200080, China. xumingyi2014@163.com
Key Words	Non-alcoholic fatty liver disease; Zinc-α2-glycoprotein 1; Tumour necrosis factor-α; Inflammation; Lipid metabolism;
Core Tip	The expressions of zinc-α2-glycoprotein 1 (AZGP1) were significantly down-regulated in liver tissues of non-alcoholic fatty liver disease (NAFLD) patients and mice. In LO2 cells, AZGP1 had the effects of alleviating NAFLD by means of blocking tumour necrosis factor-α signaling mediated inflammation, intracellular lipid deposition, proliferation and apoptosis. AZGP1 treatment could attenuate NAFLD to some extent in mice model. So AZGP1 is suggested to be a novel promising therapeutic target for NAFLD.
Citation	Liu T, Luo X, Li ZH, Wu JC, Luo SZ, Xu MY. Zinc-α2-glycoprotein 1 attenuates nonalcoholic fatty liver by negatively regulating tumour necrosis factor-α. World J Gastroenterol 2019; 25(36): 5451-5468

Received	2019-06-19 00:46
Peer-Review Started	2019-06-20 11:10
To Make the First Decision	2019-07-22 04:23
Return for Revision	2019-07-24 08:46
Revised	2019-07-26 00:11
Second Decision	2019-08-23 10:16
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-08-24 04:45
Articles in Press	2019-08-24 04:45
Publication Fee Transferred
Edit the Manuscript by Language Editor	2019-09-08 03:23
Typeset the Manuscript	2019-09-27 07:36

ISSN	1007-9327 (print) and 2219-2840 (online)
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