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Publication Name World Journal of Diabetes
Manuscript ID 49923
Country of Manuscript Source Colombia
Specialty Endocrinology and Metabolism
Manuscript type Observational Study
Article Title Type 1 diabetes loci display a variety of native American and African ancestries in diseased individuals from Northwest Colombia
Manuscript Source Unsolicited Manuscript
All Author List Natalia Gomez-Lopera, Juan M Alfaro, Suzanne M Leal and Nicolas Pineda-Trujillo
Funding Agency and Grant Number
Funding Agency Grant Number
Colciencias 111556933366
CODI- Universidad de Antioquia
Colciencias. NG-L 727cfrom 2015
Correspondence To Nicolas Pineda-Trujillo, MSc, PhD, Academic Research, Research Scientist, Senior Scientist, Grupo Mapeo Genetico, Departamento de Pediatría, Facultad de Medicina, Universidad de Antioquia, Carrera 51D No. 62-21, Medellín 050010470, Colombia. nicolas.pineda@udea.edu.co
Keywords Type 1 diabetes; Genetic admixture; Native American; Idiopathic; Colombia;
Core Tip We have tested the effect of genetic admixture in a set of Colombian patients with Type 1 Diabetes (T1D). It is shown that although globally no differences between T1D and Colombians Living in Medellin subjects arosed, there appear ancestry differences when looking at specific T1D loci/genes (e.g., genes EFR3B, IFIH1, IL7R and NRP1). Also, when comparing patients ancestry according to the presence/absence of T1D related auto-antibodies or age at onset of the disease, differences were also observed. The most striking differences in ancestry occurred outside the HLA region, which is considered the master risk locus in T1D and for autoimmune diseases overall. This is itself a striking observation.
Citation Gomez-Lopera N, Alfaro JM, Leal SM, Pineda-Trujillo N. Type 1 diabetes loci display a variety of native American and African ancestries in diseased individuals from Northwest Colombia. World J Diabetes 2019; In press
Received
2019-07-18 22:52
Peer-Review Started
2019-07-21 10:30
To Make the First Decision
2019-09-02 01:38
Return for Revision
2019-09-06 07:50
Revised
2019-09-11 23:24
Second Decision
2019-09-29 06:45
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-10-07 19:18
Articles in Press
2019-10-07 19:18
Publication Fee Transferred
Edit the Manuscript by Language Editor
2019-10-15 21:45
Typeset the Manuscript
ISSN 1948-9358 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Assistant Editor Assistant Editor
Science Editor Jia-Ping Yan
Reviewer Code 03764245, and 02510721
Editorial Director Ruo-Yu Ma
Journal Chief Editor
Company Chief Editor Na Ma
Language Editor Donna Fox
Electronic Editor
Responsible Electronic Editor
Responsible Science Editor
Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma
Manuscript File FP7041_ce25_CE1MS-edit2_ngp.docx
Answering Reviewers 49923-Answering reviewers.pdf
Audio Core Tip 49923-Audio core tip.m4a
Biostatistics Review Certificate 49923-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 49923-Conflict-of-interest statement.pdf
Copyright License Agreement 49923-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 49923-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s) 49923-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 49923-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 49923-Language certificate.pdf
Supplementary Material 49923-Supplementary material.pdf
Peer-review Report 49923-Peer-review(s).pdf
Scientific Misconduct Check 49923-Scientific misconduct check.pdf
Scientific Editor Work List 49923-Scientific editor work list.pdf