Publication Name	World Journal of Diabetes
Manuscript ID	49923
Country	Colombia

Category	Endocrinology & Metabolism
Manuscript Type	Observational Study
Article Title	Type 1 diabetes loci display a variety of native American and African ancestries in diseased individuals from Northwest Colombia
Manuscript Source	Unsolicited Manuscript
All Author List	Natalia Gomez-Lopera, Juan M Alfaro, Suzanne M Leal and Nicolas Pineda-Trujillo
Funding Agency and Grant Number	Funding Agency Grant Number Colciencias 111556933366 CODI- Universidad de Antioquia Colciencias. NG-L 727cfrom 2015
Corresponding Author	Nicolas Pineda-Trujillo, MSc, PhD, Academic Research, Research Scientist, Senior Scientist, Grupo Mapeo Genetico, Departamento de Pediatría, Facultad de Medicina, Universidad de Antioquia, Carrera 51D No. 62-21, Medellín 050010470, Colombia. nicolas.pineda@udea.edu.co
Key Words	Type 1 diabetes; Genetic admixture; Native American; Idiopathic; Colombia;
Core Tip	We have tested the effect of genetic admixture in a set of Colombian patients with Type 1 Diabetes (T1D). It is shown that although globally no differences between T1D and Colombians Living in Medellin subjects arosed, there appear ancestry differences when looking at specific T1D loci/genes (e.g., genes EFR3B, IFIH1, IL7R and NRP1). Also, when comparing patients ancestry according to the presence/absence of T1D related auto-antibodies or age at onset of the disease, differences were also observed. The most striking differences in ancestry occurred outside the HLA region, which is considered the master risk locus in T1D and for autoimmune diseases overall. This is itself a striking observation.
Citation	Gomez-Lopera N, Alfaro JM, Leal SM, Pineda-Trujillo N. Type 1 diabetes loci display a variety of native American and African ancestries in diseased individuals from Northwest Colombia. World J Diabetes 2019; 10(11): 534-545

Received	2019-07-18 22:52
Peer-Review Started	2019-07-21 10:30
To Make the First Decision	2019-09-02 01:38
Return for Revision	2019-09-06 07:50
Revised	2019-09-11 23:24
Second Decision	2019-09-29 06:45
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-10-07 19:18
Articles in Press	2019-10-07 19:18
Publication Fee Transferred
Edit the Manuscript by Language Editor	2019-10-15 21:45
Typeset the Manuscript	2019-11-01 06:07

ISSN	1948-9358 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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