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Publication Name World Journal of Gastroenterology
Manuscript ID 49977
Country of Manuscript Source South Korea
Specialty Gastroenterology and Hepatology
Manuscript type Basic Study
Article Title Superior gallstone dissolubility and safety of tert-amyl ethyl ether over methyl-tertiary butyl ether
Manuscript Source Unsolicited Manuscript
All Author List Dong Do You, Suk Joon Cho, Ok-Hee Kim, Jin Sook Song, Kyu-Seok Hwang, Sang Chul Lee, Kee-Hwan Kim, Ho Joong Choi, Ha-Eun Hong, Haeyeon Seo, Tae Ho Hong, Jung Hyun Park, Tae Yun Lee, Joseph Ahn, Jae-Kyung Jung, Kwan-Young Jung and Say-June Kim
Funding Agency and Grant Number
Funding Agency Grant Number
Catholic Medical Center Research Foundation program year of 2018
Correspondence To Say-June Kim, MD, PhD, Professor, Surgeon, Department of Surgery, Seoul St. Mary’s Hospital, College of Medicine, the Catholic University of Korea, 222, Banpo-daero, Seocho-gu, Seoul 06591, South Korea. sayjunekim@gmail.com
Keywords Tert-amyl ethyl ether; Gallstones; Methyl-tert-butyl ether; Contact litholytic agent; ;
Core Tip We developed a novel gallstone-dissolving agent, named tert-amyl ethyl ether (TAEE), an methyl-tertiary butyl ether (MTBE) analogue, with a relatively higher boiling point (102 °C). The in vitro results demonstrated a 24 h TAEE-dissolubility of 76.7%, 56.5% and 38.75% for cholesterol, mixed, and pigmented gallstones, respectively, which represented a 1.2-, 1.4-, and 1.3-fold increase in dissolubility compared to that of MTBE. In the in vivo experiment, TAEE showed a 1.4- and 1.9-fold higher dissolubility for cholesterol and pigmented gallstones than MTBE. As such, TAEE could present an attractive alternative to MTBE if further clinical studies validate its efficacy and safety.
Citation You DD, Cho SJ, Kim OH, Song JS, Hwang KS, Lee SC, Kim KH, Choi HJ, Hong HE, Seo H, Hong TH, Park JH, Lee TY, Ahn J, Jung JK, Jung KY, Kim SJ. Superior gallstone dissolubility and safety of tert-amyl ethyl ether over methyl-tertiary butyl ether. World J Gastroenterol 2019; In press
Received
2019-07-02 00:33
Peer-Review Started
2019-07-02 07:39
To Make the First Decision
2019-08-05 01:41
Return for Revision
2019-08-06 09:13
Revised
2019-08-19 08:22
Second Decision
2019-09-10 10:42
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-09-10 21:05
Articles in Press
2019-09-10 21:05
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Assistant Editor Xiang Li
Science Editor Jia-Ping Yan
Reviewer Code 03011144, and 02510721
Editorial Director Ze-Mao Gong
Journal Chief Editor
Company Chief Editor Lian-Sheng Ma
Language Editor
Electronic Editor
Responsible Electronic Editor
Responsible Science Editor
Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma
Manuscript File 49977-Review.docx
Answering Reviewers 49977-Answering reviewers.pdf
Audio Core Tip 49977-Audio core tip.mp3
Biostatistics Review Certificate 49977-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 49977-Conflict-of-interest statement.pdf
Copyright License Agreement 49977-Copyright license agreement.pdf
Institutional Animal Care and Use Committee Approval Form or Document 49977-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 49977-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 49977-Language certificate.pdf
Supplementary Material 49977-Supplementary material.pdf
Peer-review Report 49977-Peer-review(s).pdf
Scientific Misconduct Check 49977-Scientific misconduct check.pdf
Scientific Editor Work List 49977-Scientific editor work list.pdf