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Publication Name World Journal of Gastroenterology
Manuscript ID 50316
Country China
Category Gastroenterology & Hepatology
Manuscript Type Basic Study
Article Title Nucleus tractus solitarius mediates hyperalgesia induced by chronic pancreatitis in rats
Manuscript Source Unsolicited Manuscript
All Author List Yang Bai, Ying-Biao Chen, Xin-Tong Qiu, Yan-Bing Chen, Li-Tian Ma, Ying-Qi Li, Hong-Ke Sun, Ming-Ming Zhang, Ting Zhang, Tao Chen, Bo-Yuan Fan, Hui Li and Yun-Qing Li
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundations of China 81620108008
Major Research and Development Project of Hainan Province 2018153
Training Program for Scientific Research Scholars of Fujian Provincial Health and Family Planning Commission 2018-ZQN-74
Corresponding Author Yun-Qing Li, PhD, Professor, Department of Anatomy, Histology and Embryology & K. K. Leung Brain Research Centre, Fourth Military Medical University, No. 169 West Chang-le Road, Xi'an 710032, Shaanxi Province,, China. deptanat@fmmu.edu.cn
Key Words Rat; Chronic pancreatitis; Visceral hypersensitivity; The nucleus tractus solitarius; Excitatory synaptic transmission;
Core Tip This study investigates the role of the nucleus tractus solitarius (NTS) in the pathogenesis of visceral hypersensitivity in a rat model of chronic pancreatitis (CP). We demonstrated that CP rats exhibited potentiated excitatory synaptic transmission within the caudal NTS. This potentiation may be mediated by enhanced glutamate release and the recruitment of membrane glutamate receptors. Inhibiting both the excitatory synaptic transmission and neural activity of caudal NTS neurons alleviated visceral hypersensitivity in CP rats. Our results suggest the caudal NTS as a primary central site that processes pancreatic pain, as well as a potential therapeutic target for the treatment of chronic visceral pain in patients with CP.
Citation Bai Y, Chen YB, Chen YB, Ma LT, Li YQ, Sun HK, Qiu XT, Zhang T, Chen T, Fan BY, Li H, Li YQ. Nucleus tractus solitarius mediates hyperalgesia induced by chronic pancreatitis in rats. World J Gastroenterol 2019; 25(40): 6077-6093
Received
2019-07-17 23:11
Peer-Review Started
2019-07-19 07:26
To Make the First Decision
2019-08-19 00:28
Return for Revision
2019-08-23 08:44
Revised
2019-09-06 04:26
Second Decision
2019-09-10 10:52
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-09-10 21:02
Articles in Press
2019-09-10 21:02
Publication Fee Transferred
Edit the Manuscript by Language Editor
2019-09-22 14:19
Typeset the Manuscript
2019-10-25 09:27
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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