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Publication Name World Journal of Gastroenterology
Manuscript ID 50316
Country of Manuscript Source China
Specialty Gastroenterology and Hepatology
Manuscript type Basic Study
Article Title Nucleus tractus solitarius mediates hyperalgesia induced by chronic pancreatitis in rats
Manuscript Source Unsolicited Manuscript
All Author List Yang Bai, Ying-Biao Chen, Xin-Tong Qiu, Yan-Bing Chen, Li-Tian Ma, Ying-Qi Li, Hong-Ke Sun, Ming-Ming Zhang, Ting Zhang, Tao Chen, Bo-Yuan Fan, Hui Li and Yun-Qing Li
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundations of China 81620108008
Major Research and Development Project of Hainan Province 2018153
Training Program for Scientific Research Scholars of Fujian Provincial Health and Family Planning Commission 2018-ZQN-74
Correspondence To Yun-Qing Li, PhD, Professor, Department of Anatomy, Histology and Embryology & K. K. Leung Brain Research Centre, Fourth Military Medical University, No. 169 West Chang-le Road, Xi'an 710032, Shaanxi Province,, China. deptanat@fmmu.edu.cn
Keywords Rat; Chronic pancreatitis; Visceral hypersensitivity; The nucleus tractus solitarius; Excitatory synaptic transmission;
Core Tip This study investigates the role of the nucleus tractus solitarius (NTS) in the pathogenesis of visceral hypersensitivity in a rat model of chronic pancreatitis (CP). We demonstrated that CP rats exhibited potentiated excitatory synaptic transmission within the caudal NTS. This potentiation may be mediated by enhanced glutamate release and the recruitment of membrane glutamate receptors. Inhibiting both the excitatory synaptic transmission and neural activity of caudal NTS neurons alleviated visceral hypersensitivity in CP rats. Our results suggest the caudal NTS as a primary central site that processes pancreatic pain, as well as a potential therapeutic target for the treatment of chronic visceral pain in patients with CP.
Citation Bai Y, Chen YB, Chen YB, Ma LT, Li YQ, Sun HK, Qiu XT, Zhang T, Chen T, Fan BY, Li H, Li YQ. Nucleus tractus solitarius mediates hyperalgesia induced by chronic pancreatitis in rats. World J Gastroenterol 2019; In press
Received
2019-07-17 23:11
Peer-Review Started
2019-07-19 07:26
To Make the First Decision
2019-08-19 00:28
Return for Revision
2019-08-23 08:44
Revised
2019-09-06 04:26
Second Decision
2019-09-10 10:52
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-09-10 21:02
Articles in Press
2019-09-10 21:02
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Assistant Editor Assistant Editor
Science Editor Jia-Ping Yan
Reviewer Code 02650654, 03026651, 02734287, 03257825, 00182054, and 00070583
Editorial Director Ze-Mao Gong
Journal Chief Editor
Company Chief Editor Lian-Sheng Ma
Language Editor
Electronic Editor
Responsible Electronic Editor
Responsible Science Editor
Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma
Manuscript File 50316-Review.docx
Answering Reviewers 50316-Answering reviewers.pdf
Audio Core Tip 50316-Audio core tip.mp3
Biostatistics Review Certificate 50316-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 50316-Conflict-of-interest statement.pdf
Copyright License Agreement 50316-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 50316-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 50316-Institutional animal care and use committee statement.pdf
Non-Native Speakers of English Editing Certificate 50316-Language certificate.pdf
Supplementary Material 50316-Supplementary material.pdf
Peer-review Report 50316-Peer-review(s).pdf
Scientific Misconduct Check 50316-Scientific misconduct check.pdf
Scientific Editor Work List 50316-Scientific editor work list.pdf