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Publication Name World Journal of Gastroenterology
Manuscript ID 50351
Country of Manuscript Source China
Specialty Gastroenterology and Hepatology
Manuscript type Retrospective Study
Article Title Nucleoside diphosphate-linked moiety X-type motif 15 R139C genotypes impact the 6-thioguanine nucleotide cut-off levels to predict thiopurine-induced leukopenia in Crohn’s disease patients
Manuscript Source Unsolicited Manuscript
All Author List Xia Zhu, Kang Chao, Miao Li, Wen Xie, Hong Zheng, Jin-Xin Zhang, Pin-Jin Hu, Min Huang, Xiang Gao and Xue-Ding Wang
Funding Agency and Grant Number
Funding Agency Grant Number
the 111 project B16047
the National Science Foundation of China 81473283, 81173131, 81573507, and 81320108027
the Natural Major Projects for science and technology development from Science and Technology Ministry of China 2012ZX09506001-004
he Major Scientific and Technological Project of Guangdong Province 2011A080300001
Guangdong Provincial Key Laboratory of Construction Foundation 2011A060901014
Science and Technology Program of Guangzhou 2014J4100179
The National Key Research and Development Program No.2016YFC0905000
Correspondence To Xue-Ding Wang, PharmD, Professor, Teacher, Institute of Clinical Pharmacology, School of Pharmaceutical Sciences, Sun Yat-sen University Cancer Center, No. 132 Waihuan Dong Road, Guangzhou University City, Guangzhou 510006, Guangdong Province, China. wangxd@mail.sysu.edu.cn
Keywords Crohn’s disease; Thioguanine nucleotide levels; Nucleoside diphosphate-linked moiety X-type motif 15; Thiopurine-induced leukopenia; ;
Core Tip Thiopurine-induced leukopenia (TIL), a life-threatening toxicity in inflammatory bowel disease, occurs with high frequency in Asia. Although nucleoside diphosphate-linked moiety X-type motif 15 (NUDT15) significantly increases the prediction sensitivity of TIL, more than 50% of cases cannot be predicted by this mutation. The potential use of steady-state thioguanine nucleotide (6TGN) levels to predict TIL has been explored for decades, but no decisive conclusion has been reached. Can we increase the predictive sensitivity based on 6TGN by subgrouping patients according to their NUDT15 genotypes? Yes! According to our research, applying 6TGN levels to adjust thiopurine therapies based on NUDT15 is strongly recommended.
Citation Zhu X, Chao K, Li M, Xie W, Zheng H, Zhang JX, Hu PJ, Huang M, Gao X, Wang XD. Nucleoside diphosphate-linked moiety X-type motif 15 R139C genotypes impact the 6-thioguanine nucleotide cut-off levels to predict thiopurine-induced leukopenia in Crohn’s disease patients. World J Gastroenterol 2019; In press
Received
2019-07-24 08:53
Peer-Review Started
2019-07-24 08:53
To Make the First Decision
2019-08-19 00:44
Return for Revision
2019-08-23 01:53
Revised
2019-09-05 08:20
Second Decision
2019-09-10 10:59
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-09-10 20:59
Articles in Press
2019-09-10 20:59
Publication Fee Transferred
Edit the Manuscript by Language Editor
2019-09-17 01:52
Typeset the Manuscript
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Assistant Editor Assistant Editor
Science Editor Ruo-Yu Ma
Reviewer Code 03254999, and 03662987
Editorial Director Ze-Mao Gong
Journal Chief Editor
Company Chief Editor Lian-Sheng Ma
Language Editor Tian-Qi Wang
Electronic Editor
Responsible Electronic Editor
Responsible Science Editor
Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma
Manuscript File 50351-Review_Edited.docx
Answering Reviewers 50351-Answering reviewers.pdf
Audio Core Tip 50351-Audio core tip.mp3
Biostatistics Review Certificate 50351-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 50351-Conflict-of-interest statement.pdf
Copyright License Agreement 50351-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 50351-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s) 50351-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 50351-Institutional review board statement.PDF
Non-Native Speakers of English Editing Certificate 50351-Language certificate.pdf
Supplementary Material 50351-Supplementary material.pdf
Peer-review Report 50351-Peer-review(s).pdf
Scientific Misconduct Check 50351-Scientific misconduct check.pdf
Scientific Editor Work List 50351-Scientific editor work list.pdf