Publication Name	World Journal of Gastroenterology
Manuscript ID	50351
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Nucleoside diphosphate-linked moiety X-type motif 15 R139C genotypes impact the 6-thioguanine nucleotide cut-off levels to predict thiopurine-induced leukopenia in Crohn’s disease patients
Manuscript Source	Unsolicited Manuscript
All Author List	Xia Zhu, Kang Chao, Miao Li, Wen Xie, Hong Zheng, Jin-Xin Zhang, Pin-Jin Hu, Min Huang, Xiang Gao and Xue-Ding Wang
Funding Agency and Grant Number	Funding Agency Grant Number the 111 project B16047 the National Science Foundation of China 81473283, 81173131, 81573507, and 81320108027 the Natural Major Projects for science and technology development from Science and Technology Ministry of China 2012ZX09506001-004 he Major Scientific and Technological Project of Guangdong Province 2011A080300001 Guangdong Provincial Key Laboratory of Construction Foundation 2011A060901014 Science and Technology Program of Guangzhou 2014J4100179 The National Key Research and Development Program No.2016YFC0905000
Corresponding Author	Xue-Ding Wang, PharmD, Professor, Teacher, Institute of Clinical Pharmacology, School of Pharmaceutical Sciences, Sun Yat-sen University Cancer Center, No. 132 Waihuan Dong Road, Guangzhou University City, Guangzhou 510006, Guangdong Province, China. wangxd@mail.sysu.edu.cn
Key Words	Crohn’s disease; Thioguanine nucleotide levels; Nucleoside diphosphate-linked moiety X-type motif 15; Thiopurine-induced leukopenia; ;
Core Tip	Thiopurine-induced leukopenia (TIL), a life-threatening toxicity in inflammatory bowel disease, occurs with high frequency in Asia. Although nucleoside diphosphate-linked moiety X-type motif 15 (NUDT15) significantly increases the prediction sensitivity of TIL, more than 50% of cases cannot be predicted by this mutation. The potential use of steady-state thioguanine nucleotide (6TGN) levels to predict TIL has been explored for decades, but no decisive conclusion has been reached. Can we increase the predictive sensitivity based on 6TGN by subgrouping patients according to their NUDT15 genotypes? Yes! According to our research, applying 6TGN levels to adjust thiopurine therapies based on NUDT15 is strongly recommended.
Citation	Zhu X, Chao K, Li M, Xie W, Zheng H, Zhang JX, Hu PJ, Huang M, Gao X, Wang XD. Nucleoside diphosphate-linked moiety X-type motif 15 R139C genotypes impact the 6-thioguanine nucleotide cut-off levels to predict thiopurine-induced leukopenia in Crohn’s disease patients. World J Gastroenterol 2019; 25(38): 5850-5861

Received	2019-07-24 08:53
Peer-Review Started	2019-07-24 08:53
To Make the First Decision	2019-08-19 00:44
Return for Revision	2019-08-23 01:53
Revised	2019-09-05 08:20
Second Decision	2019-09-10 10:59
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-09-10 20:59
Articles in Press	2019-09-10 20:59
Publication Fee Transferred
Edit the Manuscript by Language Editor	2019-09-17 01:52
Typeset the Manuscript	2019-10-14 07:39

ISSN	1007-9327 (print) and 2219-2840 (online)
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