Publication Name	World Journal of Gastroenterology
Manuscript ID	50513
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Case Control Study
Article Title	Correlation of plasma miR-21 and miR-93 with radiotherapy and chemotherapy efficacy and prognosis in patients with esophageal squamous cell carcinoma
Manuscript Source	Unsolicited Manuscript
All Author List	Wen-Tao Wang, Chang-Qing Guo, Guang-Hui Cui and Song Zhao
Funding Agency and Grant Number
Corresponding Author	Song Zhao, MD, Doctor, Department of Thoracic Surgery, First Affiliated Hospital of Zhengzhou University, 12th floor, Building 6, Zhengzhou University first affiliated Hospital, No. 1 Longhu Middle Ring Road, Jinshui District, Zhengzhou City, Henan Province, Zhengzhou 450000, Henan Province, China. zhaosong1212@qq.com
Key Words	miR-21; miR-93; Esophageal squamous cell carcinoma; Radiotherapy and chemotherapy; Prognosis; Diagnosis
Core Tip	In order to observe the roles of miR-21 and miR-93 in radiotherapy and chemotherapy efficacy and prognosis on esophageal squamous cell carcinoma (ESCC), real time Quantitative polymerase chain reaction was adopted to determine the expressions of plasma miR-21 and miR-93 in ESCC patients. Multivariate Logistic regression analysis revealed that patients with high T stage and M stage and high expressions of miR-21(> 5.80) and miR-93 (> 4.71) suffered increased risks of ineffective radiotherapy and chemotherapy, and multivariate Cox regression analysis revealed that patients with high T stage, N stage, and M stage, and high expressions of miR-21 (> 5.60), and miR-93 (> 3.87) suffered increased risk of death in 3 years.
Citation	Wang WT, Guo CQ, Cui GH, Zhao S. Correlation of plasma miR-21 and miR-93 with radiotherapy and chemotherapy efficacy and prognosis in patients with esophageal squamous cell carcinoma. World J Gastroenterol 2019; 25(37): 5604-5618

Received	2019-07-24 08:52
Peer-Review Started	2019-07-24 08:52
To Make the First Decision	2019-08-19 00:46
Return for Revision	2019-08-23 01:14
Revised	2019-09-08 14:06
Second Decision	2019-09-10 10:57
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-09-10 21:00
Articles in Press	2019-09-10 21:00
Publication Fee Transferred
Edit the Manuscript by Language Editor	2019-09-16 23:30
Typeset the Manuscript	2019-09-27 11:15

ISSN	1007-9327 (print) and 2219-2840 (online)
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