Publication Name	World Journal of Gastroenterology
Manuscript ID	50536
Country	Serbia

Category	Gastroenterology & Hepatology
Manuscript Type	Observational Study
Article Title	Metabolic syndrome attenuates ulcerative colitis: Correlation with interleukin-10 and galectin-3 expression
Manuscript Source	Unsolicited Manuscript
All Author List	Marina Jovanovic, Bojana Simovic Markovic, Nevena Gajovic, Milena Jurisevic, Aleksandar Djukic, Ivan Jovanovic, Nebojsa Arsenijevic, Aleksandra Lukic and Natasa Zdravkovic
Funding Agency and Grant Number
Corresponding Author	Bojana Simovic Markovic, MD, PhD, Research Assistant Professor, Center for Molecular Medicine and Stem Cell Research, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, Kragujevac 34000, Serbia. ivanjovanovic77@gmail.com
Key Words	Ulcerative colitis; Metabolic syndrome; Galectin-3; Inflammation; Interleukin-10; Systemic immune response
Core Tip	Metabolic syndrome (MetS) is among most common ulcerative colitis (UC) comorbidity. Still, there is no data considering whether the comorbidity of UC and MetS affects the pathology of UC. The aim of this study was to investigate the effects of MetS on severity and immunopathology of UC. Our results revealed that patients with MetS have milder form of UC accompanied with higher level of Galectin-3 and interleukin-10 and altered functional phenotype and intracellular content of lymphocytes infiltrating affected tissue.
Citation	Jovanovic M, Simovic Markovic B, Gajovic N, Jurisevic M, Djukic A, Jovanovic I, Arsenijevic N, Lukic A, Zdravkovic N. Metabolic syndrome attenuates ulcerative colitis: Correlation with interleukin-10 and galectin-3 expression. World J Gastroenterol 2019; 25(43): 6465-6482

Received	2019-07-25 13:48
Peer-Review Started	2019-07-25 13:48
To Make the First Decision	2019-08-28 01:16
Return for Revision	2019-08-29 01:02
Revised	2019-10-24 13:36
Second Decision	2019-11-06 09:44
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-11-07 07:51
Articles in Press	2019-11-07 07:51
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2019-11-20 08:11

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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