Publication Name	World Journal of Gastroenterology
Manuscript ID	50606
Country	Italy

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Role of liver biopsy in hepatocellular carcinoma
Manuscript Source	Invited Manuscript
All Author List	Luca Di Tommaso, Marco Spadaccini, Matteo Donadon, Nicola Personeni, Abubaker Elamin, Alessio Aghemo and Ana Lleo
Funding Agency and Grant Number
Corresponding Author	Ana Lleo, MD, PhD, Associate Professor, Department of Biomedical Sciences, Humanitas University, Liver Unit, Humanitas Clinical and Research Center, Via A. Manzoni 56, Pieve Emanuele 20090, Milano, Italy. ana.lleo@humanitas.it
Key Words	Hepatocellular carcinoma; Liver biopsy; Prognostic factors; Liver cancer; Recurrence; Liquid biopsy
Core Tip	The role of liver biopsy in the diagnosis of hepatocellular carcinoma (HCC) has been challenged over time by the ability of imaging techniques to characterize liver lesions in patients with known cirrhosis; indeed, in the diagnostic algorithm for this tumor histology is currently relegated to controversial cases. However, increasing knowledge of the phenotypical and molecular characteristics of HCC is leading to a new scenario in which biopsy may play a decisive role. As the information content of the tissue sample increases, the advantages of liver biopsy may modify the current risk/benefit balance.
Citation	Di Tommaso L, Spadaccini M, Donadon M, Personeni N, Elamin A, Aghemo A, Lleo A. Role of liver biopsy in hepatocellular carcinoma. World J Gastroenterol 2019; 25(40): 6041-6052

Received	2019-07-29 19:43
Peer-Review Started	2019-07-29 19:43
To Make the First Decision	2019-08-28 01:48
Return for Revision	2019-09-04 06:21
Revised	2019-10-04 16:20
Second Decision	2019-10-16 12:36
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-10-17 06:19
Articles in Press	2019-10-17 06:19
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2019-10-25 09:25

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com