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Publication Name World Journal of Gastrointestinal Surgery
Manuscript ID 50622
Country of Manuscript Source India
Specialty Gastroenterology and Hepatology
Manuscript type Basic Study
Article Title Pathological abnormalities in splenic vasculature in non-cirrhotic portal hypertension: Its relevance in management of portal hypertension
Manuscript Source Unsolicited Manuscript
All Author List Shahana Gupta, Biju Pottakkat, Surendra Kumar Verma, Raja Kalayarasan, Sandip Chandrasekar A and Ajith Ananthakrishna Pillai
Funding Agency and Grant Number
Correspondence To Biju Pottakkat, MD, Professor, Additional Professor and Head, Department of Surgical Gastroenterology, JIPMER, Super-speciality Block 4th Floor, Pondycherry 605006, India. bijupottakkat@gmail.com
Keywords Portal hypertensive vasculopathy; Non cirrhotic portal hypertension; Splenic vasculature; Hyperdynamic circulation; Shunt surgery;
Core Tip Portal hypertensive vasculopathy is well investigated in cirrhotics. Raised portal pressure and hyperdynamic circulation are thought to be the underlying cause. Pathological changes in splenic vein are similar in cirrhotic and non-cirrhotic portal hypertensive (NCPH). They are not primarily due to venous degenerative changes and are similar to those observed in pulmonary vasculature in pulmonary hypertension. Portal hypertensive in NCPH should be viewed as systemic and pulmonary hypertension equivalent in the gastrointestinal tract. We show that these pathological venous changes in NCPH are observed in greater proportion of patients in the delayed presentation group (P < 0.003). Interventions to reduce portal pressure should therefore be initiated at diagnosis of NCPH. The damage to the vasculature starts early and can be prevented from progressing to venous thrombosis and its sequelae if early surgical intervention to reduce portal pressure is initiated.
Citation Gupta S, Pottakkat B, Verma SK, Kalayarasan R, Chandrasekar A S, Pillai AA. Pathological abnormalities in splenic vasculature in non-cirrhotic portal hypertension: Its relevance in management of portal hypertension. World J Gastrointest Surg 2019; In press
Received
2019-08-05 17:27
Peer-Review Started
2019-08-05 17:27
To Make the First Decision
2019-09-02 01:36
Return for Revision
2019-09-06 08:18
Revised
2019-09-25 17:26
Second Decision
2019-11-05 03:47
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-11-07 20:58
Articles in Press
2019-11-07 20:58
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
ISSN 1948-9366 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Assistant Editor Assistant Editor
Science Editor Jia-Ping Yan
Reviewer Code 00070537, 03563654, and 03018526
Editorial Director Ruo-Yu Ma
Journal Chief Editor
Company Chief Editor Na Ma
Language Editor
Electronic Editor
Responsible Electronic Editor
Responsible Science Editor
Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma
Manuscript File 50622-Review.docx
Answering Reviewers 50622-Answering reviewers.pdf
Audio Core Tip 50622-Audio core tip.wav
Biostatistics Review Certificate 50622-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 50622-Conflict-of-interest statement.pdf
Copyright License Agreement 50622-Copyright license agreement.pdf
Institutional Review Board Approval Form or Document 50622-Institutional review board statement.pdf
Peer-review Report 50622-Peer-review(s).pdf
Scientific Misconduct Check 50622-Scientific misconduct check.pdf
Scientific Editor Work List 50622-Scientific editor work list.pdf