Publication Name	World Journal of Gastroenterology
Manuscript ID	50734
Country	China

Category	Infectious Diseases
Manuscript Type	Observational Study
Article Title	Increased circulating circular RNA_103516 is a novel biomarker for adult inflammatory bowel disease
Manuscript Source	Unsolicited Manuscript
All Author List	Yu-Lan Ye, Juan Yin, Tong Hu, Li-Ping Zhang, Long-Yun Wu and Pang Zhi
Funding Agency and Grant Number	Funding Agency Grant Number The Natural Science Foundation of Jiangsu Province No. BK20161232 Suzhou Special Project of Diagnosis and Treatment for Key Clinical Disease No. LCZX201715
Corresponding Author	Pang Zhi, MD, Chief Doctor, Doctor, Full Professor, Department of Gastroenterology, The North District of the Affiliated Suzhou Hospital of Nanjing Medical University, No. 242 Guangji Road, Suzhou 215008, Jiangsu,, suzhou 215008, China. pangzhi0273@sina.com
Key Words	Circular RNA; Circular RNA_103516; Inflammatory bowel diseases; Biomarker; ;
Core Tip	The study aimed to assess circular RNA (circRNA)_103516 in peripheral blood mononuclear cells of inflammatory bowel disease (IBD) patients and evaluate its potential as a biomarker in Crohn’s disease and ulcerative colitis patients with regard to clinical phenotype and inflammatory cytokines. Our results showed that PBMC circRNA_103516 levels may be considered an ideal candidate biomarker for the diagnosis of IBD and has the ability to predict clinical outcomes in IBD. Dysregulation of circRNA_103516 may participate in the molecular mechanism of IBD through hsa-miR-19b-1-5p sponging.
Citation	Ye YL, Yin J, Hu T, Zhang LP, Wu LY, Pang Z. Increased circulating circular RNA_103516 is a novel biomarker for adult inflammatory bowel disease. World J Gastroenterol 2019; 25(41): 6273-6288

Received	2019-08-19 03:02
Peer-Review Started	2019-08-19 03:02
To Make the First Decision	2019-09-12 02:52
Return for Revision	2019-09-12 07:16
Revised	2019-09-23 07:05
Second Decision	2019-10-16 12:50
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-10-17 06:14
Articles in Press	2019-10-17 06:14
Publication Fee Transferred
Edit the Manuscript by Language Editor	2019-10-27 13:48
Typeset the Manuscript	2019-11-05 02:20

ISSN	1007-9327 (print) and 2219-2840 (online)
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