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10/17/2019 6:15:58 AM | Browse: 320 | Download: 583
Publication Name World Journal of Gastroenterology
Manuscript ID 50735
Country/Territory China
Category Transplantation
Manuscript Type Basic Study
Article Title Therapeutic potential of menstrual blood stem cells treating acute liver failure
Manuscript Source Unsolicited Manuscript
All Author List Pan-Pan Cen, Lin-Xiao Fan, Jie Wang, Jia-Jia Chen and Lan-Juan Li
Funding Agency and Grant Number
Funding Agency Grant Number
the State Key Laboratory for Diagnosis and Treatment of Infectious Disease
Corresponding Author Lan-Juan Li, MD, PhD, Academic Research, Doctor, Professor, Senior Researcher, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases; National Clinical Research Center for Infectious Diseases;, First Affiliated Hospital, School of Medicine, Zhejiang University, Qingchun Road 48, Shangcheng District, Hangzhou 310006, Zhejiang Province, China. ljli@zju.edu.cn
Key Words Menstrual blood stem cell; Acute liver failure; Cell transplantation; Homing; Labelling;
Core Tip In this study, we explored for the first time the therapeutic potential of intraportally transplanted menstrual blood stem cells (MenSCs) in treating pigs with acute liver failure, and showed that MenSC treatment improved liver function and coagulation, alleviated the progression of liver injury, and prolonged the survival time of pigs. Additionally, ex vivo imaging results also demonstrated the ability of MenSCs homing to pathological hepatic environments post transplantation. MenSC transplantation has the potential to be used as an available source for treating acute liver failure in future clinical therapy.
Citation Cen PP, Fan LX, Wang J, Chen JJ, Li LJ. Therapeutic potential of menstrual blood stem cells treating acute liver failure. World J Gastroenterol 2019; 25(41): 6190-6204
Received
2019-08-12 15:47
Peer-Review Started
2019-08-12 15:48
To Make the First Decision
2019-08-28 01:51
Return for Revision
2019-09-04 03:13
Revised
2019-09-26 15:07
Second Decision
2019-10-16 12:42
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-10-17 06:15
Articles in Press
2019-10-17 06:15
Publication Fee Transferred
Edit the Manuscript by Language Editor
2019-10-25 02:52
Typeset the Manuscript
2019-11-05 02:21
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
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