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Publication Name World Journal of Gastroenterology
Manuscript ID 50746
Country of Manuscript Source China
Specialty Gastroenterology and Hepatology
Manuscript Type Basic Study
Article Title Yinchenhao decoction attenuates obstructive jaundice-induced liver injury and hepatocyte apoptosis by suppressing the protein kinase RNA-like endoplasmic reticulum kinase-induced pathway
Manuscript Source Unsolicited Manuscript
All Author List Yan-Li Wu, Zhong-Lian Li, Xi-Bo Zhang and Hao Liu
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 81273952
Corresponding author Zhong-Lian Li, MD, PhD, Chief Doctor, Doctor, Professor, Surgeon, Department of Hepatobiliary and Pancreatic Surgery(2), Tianjin Nankai Hospital, 6 Changjiang Street, Nankai District, Tianjin 300100, China. NKYYLZL@163.com
Keywords Yinchenhao decoction; Obstructive jaundice; Liver injury; Apoptosis; Protein kinase RNA-like endoplasmic reticulum kinase; CCAAT/enhancer-binding protein homologous protein
Core Tip Chronic biliary obstruction results in ischaemia and hypoxia of hepatocytes and leads to apoptosis. The protein kinase RNA-like endoplasmic reticulum kinase (PERK)-induced apoptotic pathway is the main and important way, however, its role in liver injury and hepatocyte apoptosis remains unclear. Yinchenhao decoction (YCHD) can alleviate liver injury and apoptosis, whether YCHD can attenuates obstructive jaundice (OJ)-induced liver injury and hepatocyte apoptosis by inhibiting the PERK-induced pathway is still unknown. In this research study, we found that OJ induced liver injury and hepatocyte apoptosis by activating the PERK- CCAAT/enhancer-binding protein homologous protein (CHOP)-Growth arrest and DNA damage-inducible protein 34 (GADD34) pathway and upregulating the B cell lymphoma/leukemia-2 related X protein (Bax)/ B cell lymphoma/leukemia-2 (Bcl-2) ratio. YCHD attenuated these changes by inhibiting the PERK-CHOP-GADD34 pathway and Bax/Bcl-2 ratio.
Citation Wu YL, Li ZL, Zhang XB, Liu H. Yinchenhao decoction attenuates obstructive jaundice-induced liver injury and hepatocyte apoptosis by suppressing the protein kinase RNA-like endoplasmic reticulum kinase-induced pathway. World J Gastroenterol 2019; 25(41): 6205-6221
Received
2019-08-08 09:36
Peer-Review Started
2019-08-08 09:36
To Make the First Decision
2019-09-19 06:52
Return for Revision
2019-09-20 06:44
Revised
2019-09-26 19:21
Second Decision
2019-10-16 12:37
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-10-17 06:17
Articles in Press
2019-10-17 06:17
Publication Fee Transferred
Edit the Manuscript by Language Editor
2019-10-27 13:50
Typeset the Manuscript
2019-11-05 02:26
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Assistant Editor Assistant Editor
Science Editor Jin-Zhou Tang
Reviewer Code 00053659, 00503623, and 03976790
Editorial Director Ze-Mao Gong
Journal Chief Editor
Company Chief Editor Lian-Sheng Ma
Language Editor Tian-Qi Wang
Electronic Editor Yu-Jie Ma
Responsible Electronic Editor Yu-Jie Ma
Responsible Science Editor Jin-Lei Wang
Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma
Full Article (PDF) WJG-25-6205.pdf
Full Article (Word) WJG-25-6205.docx
Manuscript File 50746-Review_Edited.docx
Answering Reviewers 50746-Answering reviewers.pdf
Audio Core Tip 50746-Audio core tip.m4a
Biostatistics Review Certificate 50746-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 50746-Conflict-of-interest statement.pdf
Copyright License Agreement 50746-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 50746-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 50746-Institutional animal care and use committee statement.pdf
Non-Native Speakers of English Editing Certificate 50746-Language certificate.pdf
Peer-review Report 50746-Peer-review(s).pdf
Scientific Misconduct Check 50746-Bing-Tang JZ-2.png
Scientific Misconduct Check 50746-Scientific misconduct check.pdf
Scientific Editor Work List 50746-Scientific editor work list.pdf