Publication Name	World Journal of Gastroenterology
Manuscript ID	50746
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Yinchenhao decoction attenuates obstructive jaundice-induced liver injury and hepatocyte apoptosis by suppressing the protein kinase RNA-like endoplasmic reticulum kinase-induced pathway
Manuscript Source	Unsolicited Manuscript
All Author List	Yan-Li Wu, Zhong-Lian Li, Xi-Bo Zhang and Hao Liu
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81273952
Corresponding Author	Zhong-Lian Li, MD, PhD, Chief Doctor, Doctor, Professor, Surgeon, Department of Hepatobiliary and Pancreatic Surgery(2), Tianjin Nankai Hospital, 6 Changjiang Street, Nankai District, Tianjin 300100, China. nkyylzl@163.com
Key Words	Yinchenhao decoction; Obstructive jaundice; Liver injury; Apoptosis; Protein kinase RNA-like endoplasmic reticulum kinase; CCAAT/enhancer-binding protein homologous protein
Core Tip	Chronic biliary obstruction results in ischaemia and hypoxia of hepatocytes and leads to apoptosis. The protein kinase RNA-like endoplasmic reticulum kinase (PERK)-induced apoptotic pathway is the main and important way, however, its role in liver injury and hepatocyte apoptosis remains unclear. Yinchenhao decoction (YCHD) can alleviate liver injury and apoptosis, whether YCHD can attenuates obstructive jaundice (OJ)-induced liver injury and hepatocyte apoptosis by inhibiting the PERK-induced pathway is still unknown. In this research study, we found that OJ induced liver injury and hepatocyte apoptosis by activating the PERK- CCAAT/enhancer-binding protein homologous protein (CHOP)-Growth arrest and DNA damage-inducible protein 34 (GADD34) pathway and upregulating the B cell lymphoma/leukemia-2 related X protein (Bax)/ B cell lymphoma/leukemia-2 (Bcl-2) ratio. YCHD attenuated these changes by inhibiting the PERK-CHOP-GADD34 pathway and Bax/Bcl-2 ratio.
Citation	Wu YL, Li ZL, Zhang XB, Liu H. Yinchenhao decoction attenuates obstructive jaundice-induced liver injury and hepatocyte apoptosis by suppressing the protein kinase RNA-like endoplasmic reticulum kinase-induced pathway. World J Gastroenterol 2019; 25(41): 6205-6221

Received	2019-08-08 09:36
Peer-Review Started	2019-08-08 09:36
To Make the First Decision	2019-09-19 06:52
Return for Revision	2019-09-20 06:44
Revised	2019-09-26 19:21
Second Decision	2019-10-16 12:37
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-10-17 06:17
Articles in Press	2019-10-17 06:17
Publication Fee Transferred
Edit the Manuscript by Language Editor	2019-10-27 13:50
Typeset the Manuscript	2019-11-05 02:26

ISSN	1007-9327 (print) and 2219-2840 (online)
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