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Publication Name World Journal of Gastroenterology
Manuscript ID 50819
Country of Manuscript Source China
Specialty Gastroenterology and Hepatology
Manuscript Type Basic Study
Article Title Characterizing the composition of intestinal microflora by 16S rRNA gene sequencing
Manuscript Source Unsolicited Manuscript
All Author List Wen-Jia Wang, You-Lian Zhou, Jie He, Zhi-Qiang Feng, Long Zhang, Xiao-Bo Lai, Jun-Xiao Zhou and Hong Wang
Funding Agency and Grant Number
Funding Agency Grant Number
Guangdong Provincial Department of Science and Technology 2014A020212568
National Key Clinical Specialized Special Funds Programs of China 2013544
Corresponding author Hong Wang, MD, PhD, Chief Physician, Department of Gastroenterology,Guangzhou Digestive Disease Center, Guangzhou First People’s Hospital, South China University of Technology, No. 1 Panfu road, Yuexiu district, Guangzhou 510030, Guangdong Province, China. wong.hong@163.com
Keywords 16S rDNA; Intestinal microflora; Advanced colorectal adenoma; Colorectal cancer; Biomarkers;
Core Tip Colorectal adenoma (CRA), as the most important pre-cancerous lesion of colorectal cancer, has a close relationship with the intestinal microflora. But the mechanism is not clear. Early detection of CRA can effectively reduce the morbidity and mortality of colorectal cancer. This paper analyzes the composition and diversity of intestinal microflora in patients with CRA through 16s rDNA gene sequencing. It was proved that the diversity of intestinal microflora in patients with CRA decreased, and the increase in the number of Halomonadaceae and Shewanella algae may be biomarkers of CRA, which provides a basis for future research.
Citation Wang WJ, Zhou YL, He J, Feng ZQ, Zhang L, Lai XB, Zhou JX, Wang H. Characterizing the composition of intestinal microflora by 16S rRNA gene sequencing. World J Gastroenterol 2020; In press
Received
2019-08-13 09:14
Peer-Review Started
2019-08-13 09:14
To Make the First Decision
2019-10-14 08:55
Return for Revision
2019-10-17 02:43
Revised
2019-12-25 01:31
Second Decision
2020-01-08 09:34
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-01-11 14:20
Articles in Press
2020-01-11 14:20
Publication Fee Transferred
Edit the Manuscript by Language Editor
2020-01-16 21:24
Typeset the Manuscript
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Assistant Editor Assistant Editor
Science Editor Jia-Ping Yan
Reviewer Code 02839880, and 03442051
Editorial Director Ze-Mao Gong
Journal Chief Editor
Company Chief Editor Lian-Sheng Ma
Language Editor Donna Fox
Electronic Editor
Responsible Electronic Editor
Responsible Science Editor
Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma
Manuscript File 50819-Review-Filipodia.docx
Answering Reviewers 50819-Answering reviewers.pdf
Audio Core Tip 50819-Audio core tip.mp3
Biostatistics Review Certificate 50819-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 50819-Conflict-of-interest statement.pdf
Copyright License Agreement 50819-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 50819-Grant application form(s).pdf
Institutional Review Board Approval Form or Document 50819-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 50819-Language certificate.pdf
Peer-review Report 50819-Peer-review(s).pdf
Scientific Misconduct Check 50819-Scientific misconduct check.pdf
Scientific Editor Work List 50819-Scientific editor work list.pdf