Publication Name	World Journal of Orthopedics
Manuscript ID	50870
Country	United States

Category	Orthopedics
Manuscript Type	Basic Study
Article Title	Pilot study of a novel serum mRNA gene panel for diagnosis of acute septic arthritis
Manuscript Source	Unsolicited Manuscript
All Author List	Blake J Schultz, Timothy Sweeney, Malcolm R DeBaun, Melissa Remmel Remmel, Uros Midic, Purvesh Khatri and Michael J Gardner
Funding Agency and Grant Number
Corresponding Author	Blake J Schultz, MD, Surgeon, Orthopaedics, Stanford University, 450 Broadway Street Pavilion C, 4th Floor, Redwood City, CA 94063, United States. blakeschultzmd@gmail.com
Key Words	Biomarkers; Bioinformatics; Infection; Septic arthritis; Medical technology; Diagnostics
Core Tip	Acute septic arthritis is an orthopedic emergency. The current gold standard diagnostic tool is synovial fluid culture, but this can take days to results, so decisions about surgery are made with imperfect information. A novel diagnostic “Sepsis MetaScore” (SMS) based on an mRNA signature has been identified that uses a blood sample to rapidly identify differentiate septic vs aseptic inflammation. Our pilot study showed the SMS had higher diagnostic accuracy than current standard of care inflammatory labs, showing potential for use as a rule-out test for septic arthritis, helping to minimize misdiagnosis and avoid unnecessary surgeries.
Citation	Schultz BJ, Sweeney T, DeBaun MR, Remmel M, Midic U, Khatri P, Gardner MJ. Pilot study of a novel serum mRNA gene panel for diagnosis of acute septic arthritis. World J Orthop 2019; 10(12): 424-433

Received	2019-08-14 08:01
Peer-Review Started	2019-08-14 08:02
To Make the First Decision	2019-09-03 05:01
Return for Revision	2019-09-18 06:42
Revised	2019-09-30 05:47
Second Decision	2019-10-18 07:11
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-10-18 22:59
Articles in Press	2019-10-18 22:59
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2019-12-04 06:31

ISSN	2218-5836 (online)
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