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10/18/2019 10:59:04 PM | Browse: 253 | Download: 33
Publication Name World Journal of Orthopedics
Manuscript ID 50870
Country of Manuscript Source United States
Specialty Orthopedics
Manuscript Type Basic Study
Article Title Pilot study of a novel serum mRNA gene panel for diagnosis of acute septic arthritis
Manuscript Source Unsolicited Manuscript
All Author List Blake J Schultz, Timothy Sweeney, Malcolm R DeBaun, Melissa Remmel Remmel, Uros Midic, Purvesh Khatri and Michael J Gardner
Funding Agency and Grant Number
Corresponding author Blake J Schultz, MD, Surgeon, Orthopaedics, Stanford University, 450 Broadway Street Pavilion C, 4th Floor, Redwood City, CA94063, United States. blakeschultzmd@gmail.com
Keywords Biomarkers; Bioinformatics; Infection; Septic arthritis; Medical technology; Diagnostics
Core Tip Acute septic arthritis is an orthopedic emergency. The current gold standard diagnostic tool is synovial fluid culture, but this can take days to results, so decisions about surgery are made with imperfect information. A novel diagnostic “Sepsis MetaScore” (SMS) based on an mRNA signature has been identified that uses a blood sample to rapidly identify differentiate septic vs aseptic inflammation. Our pilot study showed the SMS had higher diagnostic accuracy than current standard of care inflammatory labs, showing potential for use as a rule-out test for septic arthritis, helping to minimize misdiagnosis and avoid unnecessary surgeries.
Citation Schultz BJ, Sweeney T, DeBaun MR, Remmel M, Midic U, Khatri P, Gardner MJ. Pilot study of a novel serum mRNA gene panel for diagnosis of acute septic arthritis. World J Orthop 2019; In press
Received
2019-08-14 08:01
Peer-Review Started
2019-08-14 08:02
To Make the First Decision
2019-09-03 05:01
Return for Revision
2019-09-18 06:42
Revised
2019-09-30 05:47
Second Decision
2019-10-18 07:11
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-10-18 22:59
Articles in Press
2019-10-18 22:59
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
ISSN 2218-5836 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Assistant Editor Assistant Editor
Science Editor Jia-Ping Yan
Reviewer Code 02456959, 00227375, and 04091933
Editorial Director Ruo-Yu Ma
Journal Chief Editor
Company Chief Editor Na Ma
Language Editor
Electronic Editor
Responsible Electronic Editor
Responsible Science Editor
Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma
Manuscript File 50870-Review.docx
Answering Reviewers 50870-Answering reviewers.pdf
Audio Core Tip 50870-Audio core tip.m4a
Biostatistics Review Certificate 50870-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 50870-Conflict-of-interest statement.pdf
Copyright License Agreement 50870-Copyright license agreement.pdf
Institutional Review Board Approval Form or Document 50870-Institutional review board statement.pdf
Peer-review Report 50870-Peer-review(s).pdf
Scientific Misconduct Check 50870-Scientific misconduct check.pdf
Scientific Editor Work List 50870-Scientific editor work list.pdf