Publication Name	World Journal of Diabetes
Manuscript ID	51033
Country	Russia

Category	Endocrinology & Metabolism
Manuscript Type	Observational Study
Article Title	Risk factors and urinary biomarkers of non-albuminuric and albuminuric chronic kidney disease in patients with type 2 diabetes
Manuscript Source	Invited Manuscript
All Author List	Anton I Korbut, Vadim V Klimontov, Ilya V Vinogradov and Vyacheslav V Romanov
Funding Agency and Grant Number
Corresponding Author	Vadim V Klimontov, DSc, MD, PhD, Professor, Laboratory of Endocrinology, Research Institute of Clinical and Experimental Lymphology – Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (RICEL – Branch of IC&G SB RAS), Timakov Street 2, Novosibirsk 630060, Russia. klimontov@mail.ru
Key Words	Diabetes mellitus; Chronic kidney disease; Albuminuria; Glomerular filtration rate; Podocytes; Risk factors
Core Tip	In this study, we demonstrate the differences in clinical and laboratory characteristics between albuminuric and non-albuminuric patterns of chronic kidney disease (CKD) in patients with long-term type 2 diabetes. Different risk factors are found for three different CKD phenotypes. We also identify differences in the urinary excretion of nephrin and podocin, two slit diaphragm proteins, and of WAP-four-disulfide core domain protein 2, a tubulointerstitial fibrosis marker, between different CKD patterns. The results further support the notion that albuminuric and non-albuminuric CKD phenotypes are different in their pathophysiology and clinical characteristics.
Citation	Korbut AI, Klimontov VV, Vinogradov IV, Romanov VV. Risk factors and urinary biomarkers of non-albuminuric and albuminuric chronic kidney disease in patients with type 2 diabetes. World J Diabetes 2019; 10(11): 517-533

Received	2019-08-26 09:27
Peer-Review Started	2019-08-26 09:29
To Make the First Decision	2019-09-23 01:00
Return for Revision	2019-09-25 07:19
Revised	2019-10-06 12:55
Second Decision	2019-10-18 08:17
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-10-18 23:05
Articles in Press	2019-10-18 23:05
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2019-11-01 06:07

ISSN	1948-9358 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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