Publication Name	World Journal of Hepatology
Manuscript ID	51183
Country	United States

Category	Gastroenterology & Hepatology
Manuscript Type	Case Report
Article Title	Successful liver transplantation for acute sickle cell intrahepatic cholestasis: A case report and review of the literature
Manuscript Source	Unsolicited Manuscript
All Author List	Motasem Alkhayyat, Mohannad Abou Saleh, Mohammad Zmaili, Vedha Sanghi, Tavankit Singh, Carol Rouphael, C Roberto Simons-Linares, Carlos Romero-Marrero, William D Carey and Christina C Lindenmeyer
Funding Agency and Grant Number
Corresponding Author	Christina C Lindenmeyer, MD, Staff Physician, Department of Gastroenterology, Hepatology & Nutrition, Cleveland Clinic, 9500 Euclid Ave Mail Code A51, Cleveland, OH 44195, United States. lindenc@ccf.org
Key Words	Case report; Sickle cell hepatopathy; Acute intrahepatic cholestasis; Liver transplant; Hepatitis C virus; Post-operative surveillance
Core Tip	Acute sickle cell intrahepatic cholestasis is a rare and life-threatening form of sickle cell hepatopathy, with a mortality rate approaching 40%. Patients typically present with fever, abdominal pain and jaundice. Rarely, it may progress to an acute liver failure phenotype, commonly associated with multi-system organ failure. Diagnosis is made after excluding other causes of acute liver injury. Treatment options include exchange blood transfusion and liver transplantation.
Citation	Alkhayyat M, Saleh MA, Zmaili M, Sanghi V, Singh T, Rouphael C, Simons-Linares CR, Romero-Marrero C, Carey WD, Lindenmeyer CC. Successful liver transplantation for acute sickle cell intrahepatic cholestasis: A case report and review of the literature. World J Hepatol 2020; 12(3): 108-115

Received	2019-09-13 16:34
Peer-Review Started	2019-09-13 16:36
To Make the First Decision	2019-10-08 00:56
Return for Revision	2019-10-08 07:58
Revised	2019-12-28 18:26
Second Decision	2020-02-14 02:13
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2020-02-18 05:54
Articles in Press	2020-02-18 05:54
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2020-03-23 02:09

ISSN	1948-5182 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com