Publication Name	World Journal of Transplantation
Manuscript ID	51316
Country	United States

Category	Transplantation
Manuscript Type	Review
Article Title	Therapeutics administered during ex vivo liver machine perfusion: An overview
Manuscript Source	Invited Manuscript
All Author List	Julianna E Buchwald, Jing Xu, Adel Bozorgzadeh and Paulo N Martins
Funding Agency and Grant Number
Corresponding Author	Paulo N Martins, MD, PhD, Assistant Professor, Attending Doctor, Surgeon, Department of Surgery, Transplant Division, University of Massachusetts Medical School, 55 Lake Ave, Worcester, MA 01655, United States. paulo.martins@umassmemorial.org
Key Words	Therapeutics; Liver transplantation; Ex vivo machine perfusion; Ischemia reperfusion injury; Organ preservation; Extended criteria donors
Core Tip	The use of extended criteria donors has increased the donor pool of available livers for transplant but has also introduced other hurdles in protecting these vulnerable organs against ischemia-reperfusion injury (IRI). Current basic science research is aimed at mitigating the effects of IRI during the transplantation process by administering therapeutics during ex vivo liver machine perfusion. Of interest include therapeutics aimed at evoking the RNA interference pathway, utilizing defatting cocktails, and administering classes of agents such as vasodilators and anti-inflammatory drugs to reduce the damage of IRI following liver procurement and transplantation for ultimate preservation of the organ.
Citation	Buchwald JE, Xu J, Bozorgzadeh A, Martins PN. Therapeutics administered during ex vivo liver machine perfusion: An overview. World J Transplant 2020; 10(1): 1-14

Received	2019-09-08 20:13
Peer-Review Started	2019-09-08 20:13
To Make the First Decision	2019-10-15 00:28
Return for Revision	2019-10-15 01:44
Revised	2019-10-26 02:19
Second Decision	2019-12-06 03:24
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-12-06 19:11
Articles in Press	2019-12-06 19:11
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2020-01-10 02:17

ISSN	2220-3230 (online)
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