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Publication Name World Journal of Gastrointestinal Oncology
Manuscript ID 51399
Country/Territory United Kingdom
Category Oncology
Manuscript Type Review
Article Title Biomarkers for detecting colorectal cancer non-invasively: DNA, RNA or proteins?
Manuscript Source Invited Manuscript
All Author List Alexandre Loktionov
Funding Agency and Grant Number
Corresponding author Alexandre Loktionov, MD, PhD, Director, CEO, Scientific director, DiagNodus Ltd, Babraham Research Campus, Bldg 280, Cambridge CB22 3AT, United Kingdom. alex.loktionov@diagnodus.com
Keywords Colorectal cancer screening; Biomarkers; Non-invasive testing; Stool; Colorectal mucus; Blood
Core Tip Numerous biomarkers detectable in non-invasively collected samples of stool, colorectal mucus, blood, urine, saliva and exhaled air are investigated to develop new tests for colorectal cancer (CRC) early detection and screening. Promising results are often reported, but it is difficult to achieve the right balance between technical complexity, cost and diagnostic performance of the new tests. Today the combination of non-invasive faecal immunochemical test and confirmatory invasive colonoscopy remains CRC screening strategy of choice. However, on-going intense research promises the emergence of new superior non-invasive screening tests that will allow for developing improved prevention strategies for these malignancies.
Citation Loktionov A. Biomarkers for detecting colorectal cancer non-invasively: DNA, RNA or proteins? World J Gastrointest Oncol 2020; 12(2): 124-148
2019-09-13 12:07
Peer-Review Started
2019-09-13 12:07
To Make the First Decision
2019-10-21 02:28
Return for Revision
2019-10-25 07:18
2019-10-30 11:24
Second Decision
2019-11-29 08:21
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-12-01 21:41
Articles in Press
2019-12-01 21:41
Publication Fee Transferred
Edit the Manuscript by Language Editor
2019-12-11 08:38
Typeset the Manuscript
2020-02-13 09:40
ISSN 1948-5204 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Assistant Editor Assistant Editor
Science Editor Ying Dou
Reviewer Code 03766000, 02941657, 03031470, 03547237, and 00070758
Editorial Director Jin-Lei Wang
Journal Chief Editor
Company Chief Editor Li Ma
Language Editor J Webster
Electronic Editor Mei-Yi Liu
Responsible Electronic Editor Lu-Lu Qi
Responsible Science Editor
Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma
Full Article (PDF) WJGO-12-124.pdf
Full Article (Word) WJGO-12-124.docx
Manuscript File 51399-Review-Webster JR.docx
Answering Reviewers 51399-Answering reviewers.pdf
Audio Core Tip 51399-Audio core tip.MP3
Conflict-of-Interest Disclosure Form 51399-Conflict-of-interest statement.pdf
Copyright License Agreement 51399-Copyright license agreement.pdf
Peer-review Report 51399-Peer-review(s).pdf
Scientific Misconduct Check 51399-Scientific misconduct check.pdf
Scientific Editor Work List 51399-Scientific editor work list.pdf