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Publication Name World Journal of Gastrointestinal Oncology
Manuscript ID 51440
Country/Territory China
Category Gastroenterology and Hepatology
Manuscript Type Basic Study
Article Title LINC00511 promotes gastric cancer cell growth by acting as a ceRNA
Manuscript Source Unsolicited Manuscript
All Author List Chong-Bing Sun, Hong-Yi Wang, Xiao-Qing Han, Yong-Ning Liu, Meng-Chun Wang, Hong-Xia Zhang, You-Feng Gu and Xiao-Gang Leng
Funding Agency and Grant Number
Corresponding author Xiao-Gang Leng, MD, Attending Doctor, Department of Anorectal Surgery, Weifang People's Hospital, No. 151 Guangwen Street, Kuiwen District, Weifang 261041, Shandong Province, China. docxiaogang@163.com
Keywords LINC00511; miR-124-3p; PDK4; Long noncoding RNAs; Gastric cancer
Core Tip In this study, we aimed to determine whether the long noncoding RNAs LINC00511 exerted its carcinogenic function in gastric cancer (GC) via the miR-124-3p/PDK4 axis. First, we investigated the expression level of LINC00511 in GC cell lines, and we then examined the biological function of LINC00511 with functional assays. Next, we predicted and confirmed the interaction between LINC00511 and miR-124-3p. Furthermore, we further found that PDK4 was a downstream target of miR-124-3p. Finally, we concluded that LINC00511 plays an oncogenic role in GC by sponging miR-124-3p and targeting PDK4, indicating that LINC00511 may be a new molecular biomarker for GC.
Citation Sun CB, Wang HY, Han XQ, Liu YN, Wang MC, Zhang HX, Gu YF, Leng XG. LINC00511 promotes gastric cancer cell growth by acting as a ceRNA. World J Gastrointest Oncol 2020; In press
Received
2019-12-21 07:51
Peer-Review Started
2019-12-21 07:51
To Make the First Decision
Return for Revision
2020-01-19 01:43
Revised
2020-02-04 09:05
Second Decision
2020-03-19 11:38
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-03-22 21:37
Articles in Press
2020-03-22 21:37
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
ISSN 1948-5204 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Assistant Editor Assistant Editor
Science Editor Jin-Lei Wang
Reviewer Code 02945676, 03115435, and 03119153
Editorial Director
Journal Chief Editor
Company Chief Editor Na Ma
Language Editor
Electronic Editor
Responsible Electronic Editor
Responsible Science Editor
Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma
Manuscript File 51440-Review.docx
Answering Reviewers 51440-Answering reviewers.pdf
Audio Core Tip 51440-Audio core tip.m4a
Biostatistics Review Certificate 51440-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 51440-Conflict-of-interest statement.pdf
Copyright License Agreement 51440-Copyright license agreement.pdf
Institutional Review Board Approval Form or Document 51440-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 51440-Language certificate.pdf
Peer-review Report 51440-Peer-review(s).pdf
Scientific Misconduct Check 51440-Scientific misconduct check.pdf
Scientific Editor Work List 51440-Scientific editor work list.pdf