Publication Name	World Journal of Gastroenterology
Manuscript ID	51535
Country	United States

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Therapies to modulate gut microbiota: Past, present and future
Manuscript Source	Invited Manuscript
All Author List	Akshita Gupta, Srishti Saha and Sahil Khanna
Funding Agency and Grant Number
Corresponding Author	Sahil Khanna, MBBS, MSc, Assistant Professor, Division of Gastroenterology and Hepatology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, United States. khanna.sahil@mayo.edu
Key Words	Fecal microbiota transplantation; Microbial replacement therapies; Clostridioides difficile infection; Microbiome; Microbiota; Inflammatory bowel disease
Core Tip	The human gut microbiota comprises of a diverse array of microorganisms responsible for the maintenance of health. Disruption of this microbial milieu has been implicated in various disorders. These include, but are not limited to, diseases such as Clostridioides difficile infection and inflammatory bowel disease. Microbial replacement therapy or fecal microbiota transplantation is highly effective for treating recurrent Clostridioides difficile infection. Its role in other gastrointestinal and non-gastrointestinal disorders is under investigation. This review summarizes the current indications and evidence for the use of such therapies, and briefly touches upon potential therapeutic applications in the future.
Citation	Gupta A, Saha S, Khanna S. Therapies to modulate gut microbiota: Past, present and future. World J Gastroenterol 2020; 26(8): 777-788

Received	2019-09-20 17:36
Peer-Review Started	2019-09-20 17:36
To Make the First Decision	2019-12-19 00:18
Return for Revision	2019-12-19 02:49
Revised	2020-02-03 16:41
Second Decision	2020-02-14 10:13
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2020-02-14 22:37
Articles in Press	2020-02-14 22:37
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2020-02-26 08:02

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com