Publication Name	World Journal of Gastroenterology
Manuscript ID	51677
Country	South Korea

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Cohort Study
Article Title	Tailored eradication vs empirical bismuth-containing quadruple therapy as first-line Helicobacter eradication: A comparative, open trial
Manuscript Source	Invited Manuscript
All Author List	Youn I Choi, Jun Won Chung, Dong Kyun Park, Kyoung Oh Kim, Kwang An Kwon, Yoon Jae Kim and Ja Young Seo
Funding Agency and Grant Number
Corresponding Author	Jun Won Chung, MD, PhD, Associate Professor, Doctor, Division of Gastroenterology, Department of Internal Medicine, Gachon University, Gil Medical Center, 21, Namdong-daero 774beon-gil, Namdong-gu, Incheon 21565, South Korea. junwonchung@hanmail.net
Key Words	Helicobacter pylori; Eradication; Tailored; Empirical; Quadruple;
Core Tip	Few studies have compared the efficacy and safety profile of a tailored eradication (TR) strategy based on the presence of a 23S ribosomal RNA point mutation with those of empirical bismuth-based quadruple therapy (EBQT) as first-line eradication for Helicobacter pylori infection in Korean patients. In this prospective, open-label, comparative study results, the first-line eradication rate of H. pylori did not statistically differ between the strategy of TR and EBQT. However, the rate of eradication-related side effects was significantly lower in TR than EBQT strategy. TR H. pylori eradication using DPO-PCR may be equally efficacious, with less treatment-related complications, compared to EBQT in Korea, where clarithromycin resistance is high.
Citation	Choi YI, Chung JW, Park DK, Kim KO, Kwon KA, Kim YJ, Seo JY. Tailored eradication vs empirical bismuth-containing quadruple therapy as first-line Helicobacter eradication: A comparative, open trial. World J Gastroenterol 2019; 25(46): 6743-6751

Received	2019-09-27 09:55
Peer-Review Started	2019-09-27 09:55
To Make the First Decision
Return for Revision	2019-11-10 05:44
Revised	2019-11-30 07:27
Second Decision	2019-12-06 07:49
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-12-06 22:17
Articles in Press	2019-12-06 22:17
Publication Fee Transferred
Edit the Manuscript by Language Editor	2019-12-10 01:44
Typeset the Manuscript	2019-12-13 06:24

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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