Publication Name	World Journal of Gastroenterology
Manuscript ID	51726
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Promising key genes associated with tumor microenvironment and prognosis of hepatocellular carcinoma
Manuscript Source	Invited Manuscript
All Author List	Long Pan, Jing Fang, Ming-Yu Chen, Shu-Ting Zhai, Bin Zhang, Zhi-Yu Jiang, Sarun Juengpanich, Yi-Fan Wang and Xiu-Jun Cai
Funding Agency and Grant Number
Corresponding Author	Xiu-Jun Cai, FACS, FRCS, MD, PhD, Doctor, Professor, Surgeon, Key Laboratory of Laparoscopic Technique Research of Zhejiang Province, department of General Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, No. 3, Qingchun East Road, Hangzhou 310016, Zhejiang Province, China. srrsh_cxj@zju.edu.cn
Key Words	Hepatocellular carcinoma; Tumor microenvironment; Differentially expressed genes; Overall survival; ;
Core Tip	We performed an integrated bioinformatics analysis to assess the influence of tumor microenvironment on the prognosis of patients with hepatocellular carcinoma (HCC). The results found that HCC patients with a high immune/stromal infiltration level had better survival benefits than patients with low infiltration level. Ten microenvironment-related key genes were screened and used to construct a prognostic gene signature, presenting good performance in predicting overall survival. Our study provided novel insight into the potential association of tumor microenvironment with HCC prognosis and molecular targeted therapy of HCC in the future.
Citation	Pan L, Fang J, Chen MY, Zhai ST, Zhang B, Jiang ZY, Juengpanich S, Wang YF, Cai XJ. Promising key genes associated with tumor microenvironment and the prognosis of hepatocellular carcinoma. World J Gastroenterol 2020; 26(8): 789-803

Received	2019-10-03 09:22
Peer-Review Started	2019-10-03 09:22
To Make the First Decision
Return for Revision	2019-11-10 05:28
Revised	2019-12-20 12:44
Second Decision	2020-02-11 11:21
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2020-02-11 19:34
Articles in Press	2020-02-11 19:34
Publication Fee Transferred
Edit the Manuscript by Language Editor	2020-02-14 08:19
Typeset the Manuscript	2020-02-26 08:13

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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