Publication Name	World Journal of Hepatology
Manuscript ID	51784
Country	United States

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Liver injury induced by paracetamol and challenges associated with intentional and unintentional use
Manuscript Source	Unsolicited Manuscript
All Author List	Laura Rotundo and Nikolaos Pyrsopoulos
Funding Agency and Grant Number
Corresponding Author	Nikolaos Pyrsopoulos, FACP, MD, PhD, Doctor, Professor, Department of Medicine, Division of Gastroenterology and Hepatology, Rutgers New Jersey Medical School, Rutgers University, New Jersey Medical School, 185 S. Orange Avenue, MSB H-535, Newark, New Jersey 07103, United States. pyrsopni@njms.rutgers.edu
Key Words	Paracetamol; Drug-induced liver injury; Hepatotoxicity; Acute liver failure; ;
Core Tip	Paracetamol is a widely used anti-pyretic that has long been established to cause liver toxicity once above therapeutic levels. Given the increased prevalence of combination medications in the form of pain relievers and antihistamines, paracetamol can be difficult to identify and remains a significant cause of acute hepatotoxicity globally. This is especially concerning given that, when co-ingested with other medications, the rise in serum paracetamol levels may be delayed and alter medical management. This review serves to describe the clinical and pathophysiologic features of hepatotoxicity secondary to paracetamol and provide an update on current available knowledge and treatment options.
Citation	Rotundo L, Pyrsopoulos N. Liver injury induced by paracetamol and challenges associated with intentional and unintentional use. World J Hepatol 2020; 12(4): 125-136

Received	2019-10-11 19:44
Peer-Review Started	2019-10-11 19:44
To Make the First Decision	2019-11-04 00:38
Return for Revision	2019-11-05 00:18
Revised	2019-12-26 19:14
Second Decision	2020-02-14 02:44
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2020-02-18 05:52
Articles in Press	2020-02-18 05:52
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2020-04-02 01:43

ISSN	1948-5182 (online)
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