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11/30/2019 3:29:10 AM | Browse: 142 | Download: 25
Publication Name World Journal of Clinical Cases
Manuscript ID 51881
Country of Manuscript Source China
Specialty Obstetrics and Gynecology
Manuscript Type Case Control Study
Article Title Oncogenic role of Tc17 cells in cervical cancer development
Manuscript Source Unsolicited Manuscript
All Author List Zun-Sheng Zhang, Ying Gu, Bing-Gang Liu, Hong Tang, Yu Hua and Jun Wang
Funding Agency and Grant Number
Corresponding author Jun Wang, MSc, Attending Doctor, Department of Obstetrics and Gynecology, Shanghai Seventh People’s Hospital, No. 358, Datong Road, Gaoqiao Town, Pudong New Area, Shanghai 200120, China. wanchuang3069629@163.com
Keywords Cervical cancer; Tc17 cells; Interleukin-17; Cancer development; Biological function; Oncogenic role
Core Tip Inflammation contributes to cancer development. Here we find that cervical cancer-elicited inflammation increases Tc17-polarizing cytokine production, which attenuates the cytotoxic CD8+ T cell development. The high amount of interleukin-17 production by Tc17 cells leads to CXCL12 upregulation and cancer cell migration. Consistent with the oncogenic role of Tc17 cells in cancer development, the ratio of cancer-infiltrating Tc17 is highly associated with poor prognosis of patients with cervical cancers. Our data thus demonstrate that Tc17 cells can be induced in cervical cancers and serve as a meaningful index in the prognosis of patients with cervical cancer.
Citation Zhang ZS, Gu Y, Liu BG, Tang H, Hua Y, Wang J. Oncogenic role of Tc17 cells in cervical cancer development. World J Clin Cases 2019; In press
Received
2019-10-07 17:19
Peer-Review Started
2019-10-07 17:20
To Make the First Decision
Return for Revision
2019-11-13 06:38
Revised
2019-11-18 13:19
Second Decision
2019-11-29 09:36
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-11-30 03:29
Articles in Press
2019-11-30 03:29
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
ISSN 2307-8960 (online)
Open Access
Copyright © The Author(s) 2019 Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Assistant Editor Assistant Editor
Science Editor Le Zhang
Reviewer Code 03670885, 02686084, and 00632018
Editorial Director
Journal Chief Editor
Company Chief Editor Lian-Sheng Ma
Language Editor
Electronic Editor
Responsible Electronic Editor
Responsible Science Editor
Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma
Manuscript File 51881-Review.docx
Answering Reviewers 51881-Answering reviewers.pdf
Audio Core Tip 51881-Audio core tip.mp3
Biostatistics Review Certificate 51881-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 51881-Conflict-of-interest statement.pdf
Copyright License Agreement 51881-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s) 51881-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 51881-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 51881-Language certificate.pdf
Peer-review Report 51881-Peer-review(s).pdf
Scientific Misconduct Check 51881-Scientific misconduct check.pdf
Scientific Editor Work List 51881-Scientific editor work list.pdf