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Articles in Press
11/30/2019 3:29:10 AM | Browse: 321 | Download: 641
| Category |
Obstetrics & Gynecology |
| Manuscript Type |
Case Control Study |
| Article Title |
Oncogenic role of Tc17 cells in cervical cancer development
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Zun-Sheng Zhang, Ying Gu, Bing-Gang Liu, Hong Tang, Yu Hua and Jun Wang |
| Funding Agency and Grant Number |
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| Corresponding Author |
Jun Wang, MSc, Attending Doctor, Department of Obstetrics and Gynecology, Shanghai Seventh People’s Hospital, No. 358, Datong Road, Gaoqiao Town, Pudong New Area, Shanghai 200120, China. wanchuang3069629@163.com |
| Key Words |
Cervical cancer; Tc17 cells; Interleukin-17; Cancer development; Biological function; Oncogenic role |
| Core Tip |
Inflammation contributes to cancer development. Here we find that cervical cancer-elicited inflammation increases Tc17-polarizing cytokine production, which attenuates the cytotoxic CD8+ T cell development. The high amount of interleukin-17 production by Tc17 cells leads to CXCL12 upregulation and cancer cell migration. Consistent with the oncogenic role of Tc17 cells in cancer development, the ratio of cancer-infiltrating Tc17 is highly associated with poor prognosis of patients with cervical cancers. Our data thus demonstrate that Tc17 cells can be induced in cervical cancers and serve as a meaningful index in the prognosis of patients with cervical cancer. |
| Citation |
Zhang ZS, Gu Y, Liu BG, Tang H, Hua Y, Wang J. Oncogenic role of Tc17 cells in cervical cancer development. World J Clin Cases 2020; 8(1): 11-19 |
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Received |
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2019-10-07 17:19 |
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Peer-Review Started |
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2019-10-07 17:20 |
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To Make the First Decision |
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Return for Revision |
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2019-11-13 06:38 |
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Revised |
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2019-11-18 13:19 |
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Second Decision |
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2019-11-29 09:36 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2019-11-30 03:29 |
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Articles in Press |
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2019-11-30 03:29 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2019-12-17 01:22 |
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Typeset the Manuscript |
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2020-01-02 08:48 |
| ISSN |
2307-8960 (online) |
| Open Access |
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| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
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