Publication Name	World Journal of Critical Care Medicine
Manuscript ID	51981
Country	India

Category	Critical Care Medicine
Manuscript Type	Observational Study
Article Title	Experience with hemoadsorption (CytoSorb<sup>®</sup>) in the management of septic shock patients
Manuscript Source	Unsolicited Manuscript
All Author List	Yatin Mehta, Chitra Mehta, Ashish Kumar, Joby V George, Aditi Gupta, Saurabh Nanda, Gaurav Kochhar and Arun Raizada
Funding Agency and Grant Number
Corresponding Author	Yatin Mehta, FRCA, MD, MNAMS, Doctor, Institute of Critical care and Anesthesia, Medanta The Medicity, Sector 38, Gurgaon 122006, Haryana, India. yatin.mehtacriticalcare@gmail.com
Key Words	Hemoadsorption; Sepsis; Cytokines; Clinical conditions; Inflammation and extracorporeal;
Core Tip	CytoSorb® is a promising new extracorporeal cytokine hemoadsorption device that can modulate the cytokine storm during sepsis. This retrospective study evaluated clinical outcomes after CytoSorb® therapy of 100 patients admitted to intensive care unit with sepsis. We observed a significant reduction in vasopressors dosage in 40 patients who survived. The survivors also had a reduction in all the biomarker levels (procalcitonin, C-reactive protein, serum lactate and bilirubin) and inflammatory markers (interleukin 6, interleukin 10 and tumour necrosis factor) after CytoSorb® therapy. Notably, 28% of patients who were given CytoSorb® therapy < 48 h after onset of septic shock survived.
Citation	Mehta Y, Mehta C, Kumar A, George JV, Gupta A, Nanda S, Kochhar G, Raizada A. Experience with hemoadsorption (CytoSorb®) in the management of septic shock patients. World J Crit Care Med 2020; 9(1): 1-12

Received	2019-10-11 11:38
Peer-Review Started	2019-10-11 11:38
To Make the First Decision	2019-11-04 00:32
Return for Revision	2019-11-05 00:24
Revised	2019-12-23 15:06
Second Decision	2020-01-13 10:41
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2020-01-13 21:39
Articles in Press	2020-01-13 21:39
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2020-01-16 09:05

ISSN	2220-3141(online)
Open Access
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