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Publication Name World Journal of Diabetes
Manuscript ID 52045
Country/Territory China
Category Cardiac & Cardiovascular Systems
Manuscript Type Systematic Reviews
Article Title Long-term effect of clopidogrel in patients with and without diabetes: A systematic review and meta-analysis of randomized controlled trials
Manuscript Source Invited Manuscript
All Author List Li-Rong Liang, Qian Ma, Lin Feng, Qi Qiu, Wen Zheng and Wu-Xiang Xie
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 81974490
Fundamental Research Funds for the Central Universities of China BMU2017YJ005
Corresponding Author Wu-Xiang Xie, PhD, Associate Professor, Peking University Clinical Research Institute, Peking University First Hospital, No. 8 Xishiku Street, Xicheng District, Beijing 100034, China. xiewuxiang@hsc.pku.edu.cn
Key Words Clopidogrel; Diabetes; Aspirin; Meta-analysis; Randomized controlled trial;
Core Tip The long-term effects of clopidogrel in patients with and without diabetes mellitus (DM) have not been systematically reviewed. The present meta-analysis firstly investigated the modifying effect of DM on the efficacy of long-term clopidogrel treatment in patients with ischemic cardiovascular disease. Although the analysis showed that the hazard ratio reduction in patients with DM was less than that in those without, this difference was not significant. The efficacy of dual antiplatelet therapy with clopidogrel and aspirin appeared to be slightly lower in patients with DM, emphasizing the need for individualized antiplatelet treatment for patients with DM after myocardial infarction or ischemic stroke.
Citation Liang LR, Ma Q, Feng L, Qiu Q, Zheng W, Xie WX. Long-term effect of clopidogrel in patients with and without diabetes: A systematic review and meta-analysis of randomized controlled trials. World J Diabetes 2020; 11(4): 137-149
Received
2019-10-15 07:57
Peer-Review Started
2019-10-15 08:00
To Make the First Decision
Return for Revision
2019-11-19 20:35
Revised
2020-01-19 03:28
Second Decision
2020-02-14 02:56
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-02-18 05:49
Articles in Press
2020-02-18 05:49
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2020-03-20 09:44
ISSN 1948-9358 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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