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Publication Name World Journal of Meta-Analysis
Manuscript ID 52097
Country of Manuscript Source United Kingdom
Specialty Medicine, Research and Experimental
Manuscript Type Systematic Review
Article Title L-carnitine supplementation in non-alcoholic fatty liver disease: A systematic review and meta-analysis
Manuscript Source Unsolicited Manuscript
All Author List Prarthana Thiagarajan, Jane Chalmers, Lu Ban, Douglas Grindlay and Guruprasad P Aithal
Funding Agency and Grant Number
Corresponding author Prarthana Thiagarajan, MBBS, MRCP, Academic Fellow, Specialist Registrar in Gastroenterology, National Institute for Health Research Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and University of Nottingham, E Floor West Block Queens Medical Centre Derby Road, Nottingham NG7 2UH, United Kingdom. prarthana.thiagarajan@nottingham.ac.uk
Keywords L-Carnitine; Non-alcoholic fatty liver disease; Nonalcoholic steatohepatitis; Liver function; Insulin resistance; Meta-analysis
Core Tip Non-Alcoholic Fatty Liver Disease (NAFLD) presents a major public health challenge. As a leading cause of abnormal liver chemistry, rising in prevalence together with obesity and insulin resistance, there is critical unmet need to identify cost-effective, population-based treatment. We synthesised evidence from randomised trials published to date evaluating the effect of dietary L-carnitine supplementation on transaminases, liver fat and insulin resistance in NAFLD. We demonstrate a significant reduction in serum alanine aminotransferase, homeostasis model of insulin resistance and liver fat with dietary L-carnitine supplementation. L-carnitine could therefore present a novel therapeutic tool for NAFLD and its metabolic associations.
Citation Thiagarajan P, Chalmers J, Ban L, Grindlay D, Aithal GP. L-carnitine supplementation in non-alcoholic fatty liver disease: A systematic review and meta-analysis. World J Meta-Anal 2020, In press
Received
2019-10-22 08:45
Peer-Review Started
2019-10-22 08:45
To Make the First Decision
2019-12-11 06:00
Return for Revision
2019-12-11 09:46
Revised
2019-12-17 13:47
Second Decision
2020-02-14 11:11
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-02-14 22:36
Articles in Press
2020-02-14 22:36
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
ISSN 2308-3840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Assistant Editor Assistant Editor
Science Editor Jie Wang
Reviewer Code 00607640, 00227368, 03293832, and 00008577
Editorial Director Jin-Lei Wang
Journal Chief Editor
Company Chief Editor Lian-Sheng Ma
Language Editor
Electronic Editor
Responsible Electronic Editor
Responsible Science Editor
Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma
Manuscript File 52097-Review.docx
Answering Reviewers 52097-Answering reviewers.pdf
Audio Core Tip 52097-Audio core tip.mp3
Biostatistics Review Certificate 52097-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 52097-Conflict-of-interest statement.pdf
Copyright License Agreement 52097-Copyright license agreement.pdf
Supplementary Material 52097-Supplementary material.pdf
Peer-review Report 52097-Peer-review(s).pdf
Scientific Misconduct Check 52097-Scientific misconduct check.pdf
Scientific Editor Work List 52097-Scientific editor work list.pdf