Publication Name	World Journal of Gastroenterology
Manuscript ID	52137
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Tea polyphenols and their chemopreventive and therapeutic effects on colorectal cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Shi-Tong Wang, Wen-Qi Cui, Dan Pan, Min Jiang, Bing Chang and Li-Xuan Sang
Funding Agency and Grant Number	Funding Agency Grant Number Innovative Talents Support Program of Institution of Higher Learning of Liaoning Province 2018-478 Innovative Talents of Science and Technology Support Program of Young and Middle Aged People of Shenyang RC170446
Corresponding Author	Li-Xuan Sang, PhD, Chief Doctor, Department of Geriatrics, the First Hospital of China Medical University, No.155, Nanjing North Street, Heping District, Shenyang 110001, Liaoning Province, China. sanglixuan2008@163.com
Key Words	Tea polyphenols; Colorectal cancer; Gut microbiota; Signal pathway; Anti-inflammation; Mechanisms
Core Tip	Colorectal cancer (CRC) has become the third most common cancer and the fourth most common cause of cancer-related death, which is involved in a series of complex mechanisms. Professors pay attention to searching for reasonable methods to prevent and treat CRC. Tea polyphenols, as natural polyphenolic phytochemicals in tea, have been proved that it can prevent and treat CRC effectively. It might become a novel medicine applied in CRC to prevent cancer and reduce the side effect of chemotherapy medicines in the future. This review summarizes the molecular mechanism of tea polyphenols acting on CRC.
Citation	Wang ST, Cui WQ, Pan D, Jiang M, Chang B, Sang LX. Tea Polyphenols and their chemopreventive and therapeutic effects on colorectal cancer. World J Gastroenterol 2020; 26(6): 562-597

Received	2019-10-19 04:21
Peer-Review Started	2019-10-19 04:23
To Make the First Decision
Return for Revision	2019-12-04 19:48
Revised	2019-12-30 03:45
Second Decision	2020-01-09 07:28
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2020-01-11 14:15
Articles in Press	2020-01-11 14:15
Publication Fee Transferred
Edit the Manuscript by Language Editor	2020-01-22 21:37
Typeset the Manuscript	2020-02-13 00:20

ISSN	1007-9327 (print) and 2219-2840 (online)
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