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Publication Name World Journal of Gastroenterology
Manuscript ID 52229
Country United States
Category Gastroenterology & Hepatology
Manuscript Type Basic Study
Article Title Magnetic resonance imaging biomarkers for pulsed focused ultrasound treatment of pancreatic ductal adenocarcinoma
Manuscript Source Unsolicited Manuscript
All Author List Ezekiel Maloney, Yak-Nam Wang, Ravneet Vohra, Helena Son, Stella Whang, Tatiana Khokhlova, Joshua Park, Kayla Gravelle, Stephanie Totten, Joo Ha Hwang and Donghoon Lee
Funding Agency and Grant Number
Funding Agency Grant Number
National Institutes of Health, National Cancer Institute R01 CA188654
National Institutes of Health, National Cancer Institute R01 CA154451
Corresponding Author Donghoon Lee, PhD, Professor, Department of Radiology, University of Washington, SLU C256, 850 Republican Street, Seattle, WA 98195, United States. dhoonlee@uw.edu
Key Words Pancreatic adenocarcinoma; Multiparametric magnetic resonance imaging; Focused ultrasound; ; ;
Core Tip In a genetic model of pancreatic ductal adenocarcinoma, clinically translatable, quantitative magnetic resonance imaging methods of T2, glycosaminoglycan chemical exchange saturation transfer, and apparent diffusion coefficient mapping were effective in non-invasively characterizing the treatment effects of pulsed focused ultrasound treatment. Pulsed focused ultrasound treatment has already been shown to improve survival for patients with pancreatic ductal adenocarcinoma in an early clinical trial, and these complimentary magnetic resonance imaging methods could help to advance this promising therapy in larger clinical trials.
Citation Maloney E, Wang YN, Vohra R, Son H, Whang S, Khokhlova T, Park J, Gravelle K, Totten S, Hwang JH, Lee D. Magnetic resonance imaging biomarkers for pulsed focused ultrasound treatment of pancreatic ductal adenocarcinoma. World J Gastroenterol 2020; 26(9): 904-917
Received
2019-11-17 04:59
Peer-Review Started
2019-11-17 05:02
To Make the First Decision
Return for Revision
2019-12-23 16:24
Revised
2020-01-12 05:23
Second Decision
2020-02-14 03:13
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-02-14 22:32
Articles in Press
2020-02-14 22:32
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2020-03-04 09:00
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
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