Publication Name	World Journal of Gastroenterology
Manuscript ID	52255
Country	Japan

Category	Immunology
Manuscript Type	Basic Study
Article Title	Kynurenine plays an immunosuppressive role in 2,4,6-trinitrobenzene sulfate-induced colitis in mice
Manuscript Source	Unsolicited Manuscript
All Author List	Chieko Tashita, Masato Hoshi, Akihiro Hirata, Kentro Nakamoto, Tatsuya Ando, Takayuki Hattori, Yasuko Yamamoto, Hiroyuki Tezuka, Hiroyuki Tomita, Akira Hara and Kuniaki Saito
Funding Agency and Grant Number	Funding Agency Grant Number Grants-in-Aids for Young Scientists (B) from the Japan Society for the Promotion of Science 17K15785 Fujita Health University Grant (2018)
Corresponding Author	Masato Hoshi, PhD, Assistant Professor, Department of Biochemical and Analytical Science, Fujita Health University Graduate School of Health Sciences, 1-98 Dengakugatsubo, Kutsukake-cho, Toyoake 470-1192, Japan. mhoshi@fujita-hu.ac.jp
Key Words	Kynurenine 3-monooxygenase; Kynurenine; Regulatory T cell; Inflammatory bowie diseases; ;
Core Tip	The role of kynurenine 3-monooxygenase (KMO) in immune regulation was examined in KMO gene deficient mice suffering from 2,4,6-trinitrobenzene sulfate-induced colitis. We demonstrated that the expression of transforming growth factor-β and interleukin-10 in the colon of these mice was upregulated by KMO inhibition and kynurenine administration, resulting in increased incidence of regulatory T cells in the inflammatory site, where they suppress progression to colitis. Thus, administration of kynurenine plays a critical role in host protection during 2,4,6-trinitrobenzene sulfate-induced colitis.
Citation	Tashita C, Hoshi M, Hirata A, Nakamoto K, Ando T, Hattori H, Yamamoto Y, Tezuka H, Tomita H, Hara A, Saito K. Kynurenine plays an immunosuppressive role in 2,4,6-trinitrobenzene sulfate-induced colitis in mice. World J Gastroenterol 2020; 26(9): 918-932

Received	2019-11-05 04:18
Peer-Review Started	2019-11-05 04:18
To Make the First Decision
Return for Revision	2019-12-23 18:24
Revised	2020-01-06 11:09
Second Decision	2020-02-20 13:51
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2020-02-21 06:05
Articles in Press	2020-02-21 06:05
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2020-03-05 01:10

ISSN	1007-9327 (print) and 2219-2840 (online)
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