Publication Name	World Journal of Gastroenterology
Manuscript ID	52287
Country	South Korea

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Bacteroides fragilis enterotoxin upregulates heme oxygenase-1 in dendritic cells via reactive oxygen species-, mitogen-activated protein kinase-, and Nrf2-dependent pathway
Manuscript Source	Invited Manuscript
All Author List	Su Hyuk Ko, Jong Ik Jeon, HA Woo and Jung Mogg Kim
Funding Agency and Grant Number	Funding Agency Grant Number Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Education, Science and Technology, South Korea NRF-2018R1D1A1B07043350
Corresponding Author	Jung Mogg Kim, MD, PhD, Chairman, Director, Doctor, Full Professor, Professor, Department of Microbiology, Hanyang University College of Medicine, Department of Microbiology and Institute of Biomedical Science, Hanyang University College of Medicine, Seoul, Korea. jungmogg@hanyang.ac.kr, Seoul 04763, South Korea. jungmogg@hanyang.ac.kr
Key Words	Bacteroides fragilis enterotoxin; Dendritic cells; Heme oxygenase-1; Mitogen-activated protein kinases; Nrf2; Signaling
Core Tip	Enterotoxigenic Bacteroides fragilis is associated with non-invasive diarrheal diseases, inflammatory bowel diseases, and colorectal cancers. Bacteroides fragilis enterotoxin (BFT) is responsible for these diseases. The present study demonstrated that signaling pathways involving ROS-mediated ERK, p38 MAPK and Nrf2 activation in dendritic cells are required for heme oxygenase-1 (HO-1) induction during exposure to BFT. This signaling pathway is different from our previous report that BFT upregulates HO-1 in intestinal epithelial cells via a p38 MAPK- and NF-κB-dependent pathway. Therefore, this is the first report concerning the effects of BFT on the HO-1 induction pathway in dendritic cells.
Citation	Ko SH, Jeon JI, Woo HA, Kim JM. Bacteroides fragilis enterotoxin upregulates heme oxygenase-1 in dendritic cells via reactive oxygen species-, mitogen-activated protein kinase-, and Nrf2-dependent pathway. World J Gastroenterol 2020; 26(3): 291-306

Received	2019-10-28 11:21
Peer-Review Started	2019-10-28 11:22
To Make the First Decision
Return for Revision	2019-12-12 13:19
Revised	2019-12-20 13:42
Second Decision	2020-01-09 07:50
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2020-01-11 14:14
Articles in Press	2020-01-11 14:14
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2020-01-15 06:32

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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