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Publication Name World Journal of Gastroenterology
Manuscript ID 52287
Country/Territory South Korea
Category Gastroenterology and Hepatology
Manuscript Type Basic Study
Article Title Bacteroides fragilis enterotoxin upregulates heme oxygenase-1 in dendritic cells via reactive oxygen species-, mitogen-activated protein kinase-, and Nrf2-dependent pathway
Manuscript Source Invited Manuscript
All Author List Su Hyuk Ko, Jong Ik Jeon, HA Woo and Jung Mogg Kim
Funding Agency and Grant Number
Funding Agency Grant Number
Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Education, Science and Technology, South Korea NRF-2018R1D1A1B07043350
Corresponding author Jung Mogg Kim, MD, PhD, Chairman, Director, Doctor, Full Professor, Professor, Department of Microbiology, Hanyang University College of Medicine, Department of Microbiology and Institute of Biomedical Science, Hanyang University College of Medicine, Seoul, Korea. jungmogg@hanyang.ac.kr, Seoul 04763, South Korea. jungmogg@hanyang.ac.kr
Keywords Bacteroides fragilis enterotoxin; Dendritic cells; Heme oxygenase-1; Mitogen-activated protein kinases; Nrf2; Signaling
Core Tip Enterotoxigenic Bacteroides fragilis is associated with non-invasive diarrheal diseases, inflammatory bowel diseases, and colorectal cancers. Bacteroides fragilis enterotoxin (BFT) is responsible for these diseases. The present study demonstrated that signaling pathways involving ROS-mediated ERK, p38 MAPK and Nrf2 activation in dendritic cells are required for heme oxygenase-1 (HO-1) induction during exposure to BFT. This signaling pathway is different from our previous report that BFT upregulates HO-1 in intestinal epithelial cells via a p38 MAPK- and NF-κB-dependent pathway. Therefore, this is the first report concerning the effects of BFT on the HO-1 induction pathway in dendritic cells.
Citation Ko SH, Jeon JI, Woo HA, Kim JM. Bacteroides fragilis enterotoxin upregulates heme oxygenase-1 in dendritic cells via reactive oxygen species-, mitogen-activated protein kinase-, and Nrf2-dependent pathway. World J Gastroenterol 2020; 26(3): 291-306
2019-10-28 11:21
Peer-Review Started
2019-10-28 11:22
To Make the First Decision
Return for Revision
2019-12-12 13:19
2019-12-20 13:42
Second Decision
2020-01-09 07:50
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-01-11 14:14
Articles in Press
2020-01-11 14:14
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2020-01-15 06:32
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Assistant Editor Assistant Editor
Science Editor Ze-Mao Gong
Reviewer Code 00410685
Editorial Director
Journal Chief Editor
Company Chief Editor Lian-Sheng Ma
Language Editor
Electronic Editor Yu-Jie Ma
Responsible Electronic Editor Yu-Jie Ma
Responsible Science Editor
Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma
Full Article (PDF) WJG-26-291.pdf
Full Article (Word) WJG-26-291.docx
Manuscript File 52287-Review.docx
Answering Reviewers 52287-Answering reviewers.pdf
Audio Core Tip 52287-Audio core tip.mp3
Biostatistics Review Certificate 52287-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 52287-Conflict-of-interest statement.pdf
Copyright License Agreement 52287-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 52287-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 52287-Institutional animal care and use committee statement.pdf
Non-Native Speakers of English Editing Certificate 52287-Language certificate.pdf
Peer-review Report 52287-Peer-review(s).pdf
Scientific Misconduct Check 52287-Scientific misconduct check.pdf
Scientific Editor Work List 52287-Scientific editor work list.pdf