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Publication Name World Journal of Gastrointestinal Oncology
Manuscript ID 52574
Country/Territory Germany
Category Methodology
Manuscript Type Evidence-Based Medicine
Article Title Adjuvant chemotherapy in curatively resected rectal cancer: How valid are the data?
Manuscript Source Unsolicited Manuscript
All Author List Giulia Manzini, Fabius Hapke, Ian N Hines, Doris Henne-Bruns and Michael Kremer
Funding Agency and Grant Number
Corresponding author Giulia Manzini, MD, MSc, Doctor, Surgeon, Department of General and Visceral Surgery, University of Ulm, Albert-Einstein-Allee 23, Ulm 89081, Germany. giulia.manzini@uniklinik-ulm.de
Keywords Rectal cancer; Validity; Meta-analysis; CONSORT checklist; Postoperative chemotherapy; Overall survival
Core Tip The role of adjuvant chemotherapy (CTx) in curatively resected rectal cancer needs to be considered cautiously. Petersen et al. published a Cochrane review in 2012 which found an improvement in survival in patients receiving adjuvant CTx after surgery in comparison to those who were treated by surgery only. The result was based on 21 studies, 5 of them supporting the advantage of CTx. Among these, we selected the three most powerful studies and assessed their validity, which was poor. Surprisingly, our meta-analysis without these studies yielded similar results as the original study (still in favor of adjuvant CTx).
Citation Manzini G, Hapke F, Hines IN, Henne-Bruns D, Kremer M. Adjuvant chemotherapy in curatively resected rectal cancer: How valid are the data? World J Gastrointest Oncol 2020; In press
Received
2019-11-07 10:40
Peer-Review Started
2019-11-07 10:40
To Make the First Decision
Return for Revision
2019-12-05 18:55
Revised
2020-02-27 09:33
Second Decision
2020-03-19 10:58
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-03-22 21:36
Articles in Press
2020-03-22 21:36
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
ISSN 1948-5204 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Assistant Editor Assistant Editor
Science Editor Yu-Qiao Wang
Reviewer Code 00183086, 03478911, and 03806663
Editorial Director
Journal Chief Editor
Company Chief Editor Na Ma
Language Editor
Electronic Editor
Responsible Electronic Editor
Responsible Science Editor
Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma
Manuscript File 52574-Review.docx
Answering Reviewers 52574-Answering reviewers.pdf
Audio Core Tip 52574-Audio core tip.m4a
Biostatistics Review Certificate 52574-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 52574-Conflict-of-interest statement.pdf
Copyright License Agreement 52574-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate 52574-Language certificate.pdf
Peer-review Report 52574-Peer-review(s).pdf
Scientific Misconduct Check 52574-Scientific misconduct check.pdf
Scientific Editor Work List 52574-Scientific editor work list.pdf