Publication Name	World Journal of Gastroenterology
Manuscript ID	52599
Country	Japan

Category	Gastroenterology & Hepatology
Manuscript Type	Systematic Reviews
Article Title	Programmed cell death-1 inhibitor-related sclerosing cholangitis: A systematic review
Manuscript Source	Invited Manuscript
All Author List	Takumi Onoyama, Yohei Takeda, Taro Yamashita, Wataru Hamamoto, Yuri Sakamoto, Hiroki Koda, Soichiro Kawata, Kazuya Matsumoto and Hajime Isomoto
Funding Agency and Grant Number
Corresponding Author	Takumi Onoyama, MD, PhD, Doctor, Department of Multidisciplinary Internal Medicine, Tottori University, 36-1 Nishi-cho, Yonago 683-8504, Tottori prefecture, Japan. golf4to@yahoo.co.jp
Key Words	Nivolumab; Pembrolizumab; Avelumab; Durvalumab; Atezolizumab; Programmed cell death-1 inhibitor
Core Tip	This study systematically reviewed the literature on the programmed cell death-1 inhibitor-related sclerosing cholangitis. Biliary dilation without obstruction, diffuse hypertrophy of the extrahepatic biliary tract and/or multiple strictures of intrahepatic biliary tract, liver dysfunction with a notable increase in biliary tract enzymes relative to hepatic enzymes, normal level of the serum immunoglobulin G4, and a moderate to poor response to steroid therapy, and CD8+ T cell infiltration in the biliary tract were clinical and pathological features of programmed cell death-1 inhibitor-related sclerosing cholangitis.
Citation	Onoyama T, Takeda Y, Yamashita T, Hamamoto W, Sakamoto Y, Koda H, Kawata S, Matsumoto K, Isomoto H. Programmed cell death-1 inhibitor-related sclerosing cholangitis: A systematic review. World J Gastroenterol 2020; 26(3): 353-365

Received	2019-11-23 07:19
Peer-Review Started	2019-11-23 07:19
To Make the First Decision
Return for Revision	2019-12-23 14:08
Revised	2020-01-07 11:13
Second Decision	2020-01-09 09:28
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2020-01-11 14:04
Articles in Press	2020-01-11 14:04
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2020-01-13 14:02

ISSN	1007-9327 (print) and 2219-2840 (online)
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