Publication Name	World Journal of Gastroenterology
Manuscript ID	52645
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Role of Tenascin-X in regulating the TGF-β/Smad signaling pathway in the pathogenesis of slow transit constipation
Manuscript Source	Unsolicited Manuscript
All Author List	Yi-Chao Zhang, Bao-Xiang Chen, Cong-Qing Jiang, Xiao-Yu Xie, Yan Zhou and Qun Qian
Funding Agency and Grant Number
Corresponding Author	Cong-Qing Jiang, PhD, Professor, Surgeon, Colorectal Surgery Department, Zhongnan Hosptial of Wuhan University, No. 169 East Lake Road, Wuchang District, Wuhan 430071, Hubei, China. wb002554@whu.edu.cn
Key Words	Slow transit constipation; Tenascin-X; Extracellular matrix glycoproteins; TGF-β; ;
Core Tip	There are couplers of results in this paper may be found interested by the general readers. The extracellular matrix protein Tenascin-X may activate the TGF-β/Smad signaling pathway by upregulating the Smad2/3 signaling protein and thereby induce slight or complete epithelial stromal cell transformation, leading to an abnormal distribution and dysfunction of interstitial cells of Cajal in the diseased colon, which promotes the occurrence and development of slow transit constipation.
Citation	Zhang YC, Chen BX, Xie XY, Zhou Y, Qian Q, Jiang CQ. Role of Tenascin-X in regulating the TGF-β/Smad signaling pathway in the pathogenesis of slow transit constipation. World J Gastroenterol 2020; 26(7): 717-724

Received	2019-11-18 06:15
Peer-Review Started	2019-11-18 06:15
To Make the First Decision
Return for Revision	2019-12-23 16:11
Revised	2020-01-07 01:21
Second Decision	2020-01-09 11:34
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2020-01-11 14:07
Articles in Press	2020-01-11 14:07
Publication Fee Transferred
Edit the Manuscript by Language Editor	2020-01-19 01:50
Typeset the Manuscript	2020-02-12 10:37

ISSN	1007-9327 (print) and 2219-2840 (online)
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