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Publication Name World Journal of Gastroenterology
Manuscript ID 52645
Country/Territory China
Category Gastroenterology and Hepatology
Manuscript Type Basic Study
Article Title Role of Tenascin-X in regulating the TGF-β/Smad signaling pathway in the pathogenesis of slow transit constipation
Manuscript Source Unsolicited Manuscript
All Author List Yi-Chao Zhang, Bao-Xiang Chen, Cong-Qing Jiang, Xiao-Yu Xie, Yan Zhou and Qun Qian
Funding Agency and Grant Number
Corresponding author Cong-Qing Jiang, PhD, Professor, Surgeon, Colorectal Surgery Department, Zhongnan Hosptial of Wuhan University, No. 169 East Lake Road, Wuchang District, Wuhan 430071, Hubei, China. wb002554@whu.edu.cn
Keywords Slow transit constipation; Tenascin-X; Extracellular matrix glycoproteins; TGF-β; ;
Core Tip There are couplers of results in this paper may be found interested by the general readers. The extracellular matrix protein Tenascin-X may activate the TGF-β/Smad signaling pathway by upregulating the Smad2/3 signaling protein and thereby induce slight or complete epithelial stromal cell transformation, leading to an abnormal distribution and dysfunction of interstitial cells of Cajal in the diseased colon, which promotes the occurrence and development of slow transit constipation.
Citation Zhang YC, Chen BX, Xie XY, Zhou Y, Qian Q, Jiang CQ. Role of Tenascin-X in regulating the TGF-β/Smad signaling pathway in the pathogenesis of slow transit constipation. World J Gastroenterol 2020; 26(7): 717-724
Received
2019-11-18 06:15
Peer-Review Started
2019-11-18 06:15
To Make the First Decision
Return for Revision
2019-12-23 16:11
Revised
2020-01-07 01:21
Second Decision
2020-01-09 11:34
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-01-11 14:07
Articles in Press
2020-01-11 14:07
Publication Fee Transferred
Edit the Manuscript by Language Editor
2020-01-19 01:50
Typeset the Manuscript
2020-02-12 10:37
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Assistant Editor Assistant Editor
Science Editor Le Zhang
Reviewer Code 00182114
Editorial Director
Journal Chief Editor
Company Chief Editor Lian-Sheng Ma
Language Editor Tian-Qi Wang
Production Editor Ji-Hong Liu
Responsible Production Editor Yu-Jie Ma
Responsible Science Editor
Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma
Full Article (PDF) WJG-26-717.pdf
Full Article (Word) WJG-26-717.docx
Manuscript File 52645-Review_WangTQ.docx
Answering Reviewers 52645-Answering reviewers.pdf
Audio Core Tip 52645-Audio core tip.m4a
Biostatistics Review Certificate 52645-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 52645-Conflict-of-interest statement.pdf
Copyright License Agreement 52645-Copyright license agreement.pdf
Institutional Review Board Approval Form or Document 52645-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 52645-Language certificate.pdf
Peer-review Report 52645-Peer-review(s).pdf
Scientific Misconduct Check 52645-Scientific misconduct check.pdf
Scientific Editor Work List 52645-Scientific editor work list.pdf