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Publication Name World Journal of Gastrointestinal Pathophysiology
Manuscript ID 52967
Country/Territory United Kingdom
Category Gastroenterology and Hepatology
Manuscript Type Review
Article Title Pancreatic exocrine insufficiency after pancreaticoduodenectomy: Current evidence and management
Manuscript Source Invited Manuscript
All Author List Adithya M Pathanki, Joseph A Attard, Elizabeth Bradley, Sarah Powell-Brett, Bobby V M Dasari, John R Isaac, Keith J Roberts and Nikolaos A Chatzizacharias
Funding Agency and Grant Number
Corresponding author Nikolaos A Chatzizacharias, FRCS (Gen Surg), MD, PhD, Surgeon, Department of HPB and liver transplantation, Queen Elizabeth Hospital, University Hospitals Birmingham, 3rd Floor, Nuffield House, Mindelsohn way, Birmingham B15 2TH, United Kingdom. chatzizacharias@gmail.com
Keywords Pancreatic exocrine insufficiency; Pancreaticoduodenectomy; Pancreatic enzyme replacement therapy; Pancreatic cancer; Malabsorption; Steatorrhoea
Core Tip Pancreatic exocrine insufficiency is highly prevalent after pancreaticoduodenectomy and has significant implications to patients’ quality of life, nutrition, post-operative survival and cancer related outcomes. The published literature reveals no uniform definition of pancreatic exocrine insufficiency in this setting and patients are often underdiagnosed. Pancreatic enzyme replacement therapy is effective, well tolerated and is indicated in this cohort of patients either routinely or at diagnosis of exocrine insufficiency. Future studies need to concentrate on the identification of a well-tolerated, reliable and reproducible diagnostic test in this setting.
Citation Pathanki AM, Attard JA, Bradley E, Powell-Brett S, Dasari BVM, Isaac JR, Roberts KJ, Chatzizacharias NA. Pancreatic exocrine insufficiency after pancreaticoduodenectomy: Current evidence and management. World J Gastrointest Pathophysiol 2020; 11(2): 20-31
2019-12-02 18:08
Peer-Review Started
2019-12-02 18:09
To Make the First Decision
Return for Revision
2019-12-23 16:39
2020-03-13 21:45
Second Decision
2020-03-19 10:40
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-03-22 21:42
Articles in Press
2020-03-22 21:42
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2020-04-08 02:45
ISSN 2150-5330 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Assistant Editor Assistant Editor
Science Editor Le Zhang
Reviewer Code 01489017, and 03261990
Editorial Director
Journal Chief Editor
Company Chief Editor Na Ma
Language Editor
Electronic Editor Lu-Lu Qi
Responsible Electronic Editor Lu-Lu Qi
Responsible Science Editor
Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma
Full Article (PDF) WJGP-11-20.pdf
Full Article (Word) WJGP-11-20.docx
Manuscript File 52967-Review.docx
Answering Reviewers 52967-Answering reviewers.pdf
Audio Core Tip 52967-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 52967-Conflict-of-interest statement.pdf
Copyright License Agreement 52967-Copyright license agreement.pdf
Peer-review Report 52967-Peer-review(s).pdf
Scientific Misconduct Check 52967-Scientific misconduct check.pdf
Scientific Editor Work List 52967-Scientific editor work list.pdf