Publication Name	World Journal of Diabetes
Manuscript ID	53065
Country	Netherlands

Category	Endocrinology & Metabolism
Manuscript Type	Review
Article Title	Fundamentals about onset and progressive disease character of type 2 diabetes mellitus
Manuscript Source	Invited Manuscript
All Author List	Rob NM Weijers
Funding Agency and Grant Number
Corresponding Author	Rob NM Weijers, PhD, Teacher, Teaching Hospital, Onze Lieve Vrouwe Gasthuis, Oosterparkstraat 9, PO Box 95500, Amsterdam 1090, Netherlands. robw01@xs4all.nl
Key Words	ATP; Free fatty acid; Glucose transporter; Membrane flexibility; Metformin; Slow-down principle; Type 2 diabetes; Unsaturation index
Core Tip	To maximize type 2 diabetes care the assessment of unsaturation index, as observed in erythrocytes, is strongly indicated with intervals of three months. The value of unsaturation index is a reliable parameter for controlling the acyl composition of phospholipids as modulators of membrane flexibility. Given the main role of free fatty acids in this process the assessment of free fatty acids instead of triglycerides assessment may be of benefit for monthly monitoring purposes. Counseling of exercise should be an essential element of the type 2 diabetes management plan.
Citation	Weijers RNM. Fundamentals about onset and progressive disease character of type 2 diabetes mellitus. World J Diabetes 2020; 11(5): 165-181

Received	2019-12-20 22:22
Peer-Review Started	2019-12-20 22:22
To Make the First Decision
Return for Revision	2020-01-06 21:46
Revised	2020-01-14 13:36
Second Decision	2020-04-08 13:47
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2020-04-09 00:28
Articles in Press	2020-04-09 00:28
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2020-05-08 08:18

ISSN	1948-9358 (online)
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