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Publication Name World Journal of Gastrointestinal Oncology
Manuscript ID 53160
Country China
Category Gastroenterology & Hepatology
Manuscript Type Retrospective Study
Article Title Perineural invasion of hilar cholangiocarcinoma in Chinese population: One center’s experience
Manuscript Source Unsolicited Manuscript
All Author List Cheng-Gang Li, Zhi-Peng Zhou, Xiang-Long Tan and Zhi-Ming Zhao
Funding Agency and Grant Number
Corresponding Author Cheng-Gang Li, MD, PhD, Associate Professor, Second Department of Hepatobiliary Surgery, Chinese PLA General Hospital, 28 Fuxing Road, Beijing 100853, China. lcgang301@126.com
Key Words Hilar cholangiocarcinoma; Perineural invasion; Pathology; Nerve plexus; Incidence; Treatment
Core Tip The aim of this study was to summarize the incidence of perineural invasion (PNI) in hilar cholangiocarcinoma (HCCA), and provide the distribution of nerve plexuses around hepatic portal to clinical surgeons. Totally 75 patients with HCCA were investigated to summarize the incidence and modes of PNI. Sections of hepatoduodenal ligament from 5 autopsy cases were scanned to display the distribution of nerve plexuses around hepatic portal. The overall incidence of PNI in this study was 92% and three nerve plexuses in the hepatoduodenal ligament and Glisson’s sheath were classified and they all surrounded the great vessels very closely. PNI is grossly underreported in HCCA and it should be considered when stratifying HCCA patients for further adjuvant treatment.
Citation Li CG, Zhou ZP, Tan XL, Zhao ZM. Perineural invasion of hilar cholangiocarcinoma in Chinese population: One center’s experience. World J Gastrointest Oncol 2020; 12(4): 457-466
Received
2019-12-23 00:18
Peer-Review Started
2019-12-23 00:18
To Make the First Decision
Return for Revision
2020-01-19 03:08
Revised
2020-01-29 15:21
Second Decision
2020-02-14 04:54
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-02-18 05:32
Articles in Press
2020-02-18 05:32
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2020-03-09 01:29
ISSN 1948-5204 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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