Publication Name	World Journal of Diabetes
Manuscript ID	53262
Country	Italy

Category	Genetics & Heredity
Manuscript Type	Review
Article Title	Shared (epi)genomic background connecting neurodegenerative diseases and type 2 diabetes
Manuscript Source	Invited Manuscript
All Author List	Valerio Caputo, Andrea Termine, Claudia Strafella, Emiliano Giardina and Raffaella Cascella
Funding Agency and Grant Number
Corresponding Author	Emiliano Giardina, PhD, Associate Professor, Molecular Genetics Laboratory UILDM, Santa Lucia Foundation, Via Ardeatina 354, Rome 00142, Italy. emiliano.giardina@uniroma2.it
Key Words	Type 2 diabetes; Alzheimer’s disease; Parkinson’s disease; Metabolism; Neurodegeneration; Neuroinflammation; Genetic variants; Epigenomic background; Disease interactome
Core Tip	Populations’ progressive aging raises important challenges to be faced, including the increased prevalence of metabolic, neurodegenerative and movement disorders, especially of type 2 diabetes, Alzheimer’s disease and Parkinson’s disease. These disorders are characterized by a multifactorial etiology, involving genetic and non-genetic factors, which may overlap. This review will discuss the shared (epi)genomic features, the role of mutually-associated genetic variants, common gene expression profiles and epigenetic background leading to development and progression of such disorders. Overall, this review highlights the importance of characterizing the “disease interactome” in order to establish adequate personalized and preventative healthcare approaches for the ageing populations.
Citation	Caputo V, Termine A, Strafella C, Giardina E, Cascella R. Shared (epi)genomic background connecting neurodegenerative diseases and type 2 diabetes. World J Diabetes 2020; 11(5): 155-164

Received	2019-12-27 14:06
Peer-Review Started	2019-12-27 14:10
To Make the First Decision
Return for Revision	2020-01-28 20:56
Revised	2020-02-10 18:04
Second Decision	2020-03-19 09:52
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2020-03-22 21:19
Articles in Press	2020-03-22 21:19
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2020-04-26 01:42

ISSN	1948-9358 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
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