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3/22/2020 9:19:28 PM | Browse: 29 | Download: 9
Publication Name World Journal of Diabetes
Manuscript ID 53262
Country/Territory Italy
Category Genetics and Heredity
Manuscript Type Review
Article Title Shared (epi)genomic background connecting neurodegenerative diseases and type 2 diabetes
Manuscript Source Invited Manuscript
All Author List Valerio Caputo, Andrea Termine, Claudia Strafella, Emiliano Giardina and Raffaella Cascella
Funding Agency and Grant Number
Corresponding author Emiliano Giardina, PhD, Associate Professor, Molecular Genetics Laboratory UILDM, Santa Lucia Foundation, Via Ardeatina 354, Rome 00142, Italy. emiliano.giardina@uniroma2.it
Keywords Type 2 diabetes; Alzheimer’s disease; Parkinson’s disease; Metabolism; Neurodegeneration; Neuroinflammation; Genetic variants; Epigenomic background; Disease interactome
Core Tip Populations’ progressive aging raises important challenges to be faced, including the increased prevalence of metabolic, neurodegenerative and movement disorders, especially of type 2 diabetes, Alzheimer’s disease and Parkinson’s disease. These disorders are characterized by a multifactorial etiology, involving genetic and non-genetic factors, which may overlap. This review will discuss the shared (epi)genomic features, the role of mutually-associated genetic variants, common gene expression profiles and epigenetic background leading to development and progression of such disorders. Overall, this review highlights the importance of characterizing the “disease interactome” in order to establish adequate personalized and preventative healthcare approaches for the ageing populations.
Citation Caputo V, Termine A, Strafella C, Giardina E, Cascella R. Shared (epi)genomic background connecting neurodegenerative diseases and type 2 diabetes. World J Diabetes 2020; In press
Received
2019-12-27 14:06
Peer-Review Started
2019-12-27 14:10
To Make the First Decision
Return for Revision
2020-01-28 20:56
Revised
2020-02-10 18:04
Second Decision
2020-03-19 09:52
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-03-22 21:19
Articles in Press
2020-03-22 21:19
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
ISSN 1948-9358 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Assistant Editor Assistant Editor
Science Editor Ze-Mao Gong
Reviewer Code 02904354, and 02950171
Editorial Director
Journal Chief Editor
Company Chief Editor Na Ma
Language Editor
Electronic Editor
Responsible Electronic Editor
Responsible Science Editor
Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma
Manuscript File 53262-Review.docx
Answering Reviewers 53262-Answering reviewers.pdf
Audio Core Tip 53262-Audio core tip.m4a
Conflict-of-Interest Disclosure Form 53262-Conflict-of-interest statement.pdf
Copyright License Agreement 53262-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate 53262-Language certificate.pdf
Peer-review Report 53262-Peer-review(s).pdf
Scientific Misconduct Check 53262-Scientific misconduct check.pdf
Scientific Editor Work List 53262-Scientific editor work list.pdf