Publication Name	World Journal of Clinical Oncology
Manuscript ID	53576
Country	United Kingdom

Category	Oncology
Manuscript Type	Retrospective Study
Article Title	Prognostic importance of lymph node yield after curative resection of gastroenteropancreatic neuroendocrine tumours
Manuscript Source	Invited Manuscript
All Author List	Jaseela Chiramel, Rose Almond, Astrid Slagter, Adeel Khan, Xin Wang, Kok Haw Jonathan Lim, Melissa Frizziero, Bipasha Chakrabarty, Annamaria Minicozzi, Angela Lamarca, Wasat Mansoor, Richard A Hubner, Juan William Valle and Mairéad Geraldine McNamara
Funding Agency and Grant Number
Corresponding Author	Mairéad Geraldine McNamara, BM BCh, MD, MSc, PhD, Attending Doctor, Senior Lecturer, Senior Researcher, Department of Medical Oncology, The Christie NHS Foundation Trust, 550 Wilmslow Road, Manchester M20 4BX, United Kingdom. mairead.mcnamara@christie.nhs.uk
Key Words	Well differentiated neuroendocrine tumours; Pancreatic neuroendocrine tumours; Small intestinal neuroendocrine tumours; Ki67; Lymph node ratio; Lymph node retrieval
Core Tip	There is no consensus on the optimal number of lymph node (LN) retrieval in patients undergoing resection for gastroenteropancreatic neuroendocrine tumours (GEP NETs). The purpose of this study was to evaluate the LN status and yield on relapse-free survival and overall survival in patients with resected GEP NETs. By using the outcome-oriented approach to cut-point analysis, this study suggested a retrieval of a minimum of eight or more LNs in patients with GEP NETs undergoing curative surgery. The risk of relapse was high in patients who had ≥ 8 LNs retrieved and a high LN yield and LN positivity were seen in small intestinal NETs and pancreatic NETs. The localisation has a significant association with relapse-free survival, necessitating stricter surveillance especially for intestinal NETs and pancreatic NETs.
Citation	Chiramel J, Almond R, Slagter A, Khan A, Wang X, Lim KHJ, Frizziero M, Chakrabarty B, Minicozzi A, Lamarca A, Mansoor W, Hubner RA, Valle JW, McNamara MG. Prognostic importance of lymph node yield after curative resection of gastroenteropancreatic neuroendocrine tumours. World J Clin Oncol 2020; 2020; 11(4): 205-216

Received	2019-12-24 17:33
Peer-Review Started	2019-12-24 17:33
To Make the First Decision
Return for Revision	2020-02-20 05:48
Revised	2020-04-05 13:38
Second Decision	2020-04-08 13:54
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2020-04-09 00:24
Articles in Press	2020-04-09 00:24
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2020-04-17 02:27

ISSN	2218-4333 (online)
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