Publication Name	World Journal of Gastroenterology
Manuscript ID	53658
Country/Territory	Japan

Category	Immunology
Manuscript Type	Review
Article Title	Vaccine therapy for dysbiosis-related diseases
Manuscript Source	Invited Manuscript
All Author List	Kosuke Fujimoto and Satoshi Uematsu
Funding Agency and Grant Number	Funding Agency Grant Number Ministry of Education, Culture, Sports, Science, and Technology of Japan (Grant-in-Aid for Early-Career Scientists) 19K17932
Corresponding author	Satoshi Uematsu, MD, PhD, Professor, Department of Immunology and Genomics, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi, Abeno-ku, Osaka 545-8585, Japan. uematsu.satoshi@med.osaka-cu.ac.jp
Keywords	Dysbiosis; IgA; Microbiome; Mucosal immunity; Pathobiont; Vaccine
Core Tip	How to control intestinal pathogenic bacteria that mediate multifactorial diseases is a major concern worldwide. There are few methods for controlling only intestinal pathogenic bacteria; therefore, we have developed a prime–boost type, next-generation mucosal vaccine, and have used it for control of bacterial intestinal diseases. This vaccine can contribute to prevention of Clostridium ramosum-mediated obesity. Thus, this approach might be useful for protecting against microbe-associated disorders of the intestine.
Citation	Fujimoto K, Uematsu S. Vaccine therapy for dysbiosis-related diseases. World J Gastroenterol 2020; In press

Received	2019-12-27 11:06
Peer-Review Started	2019-12-27 11:12
To Make the First Decision
Return for Revision	2020-02-14 17:43
Revised	2020-03-27 11:36
Second Decision	2020-05-22 09:56
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2020-05-23 01:04
Articles in Press	2020-05-23 01:04
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Assistant Editor	Assistant Editor
Science Editor	Jin-Lei Wang
Reviewer Code	03764321
Editorial Director
Journal Chief Editor
Company Chief Editor	Lian-Sheng Ma
Language Editor
Electronic Editor
Responsible Electronic Editor
Responsible Science Editor
Proofing Editorial Director	Jin-Lei Wang
Proofing Editor-in-Chief	Lian-Sheng Ma

Manuscript File	53658-Review.docx
Answering Reviewers	53658-Answering reviewers.pdf
Audio Core Tip	53658-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	53658-Conflict-of-interest statement.pdf
Copyright License Agreement	53658-Copyright license agreement.PDF
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	53658-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate	53658-Language certificate.pdf
Peer-review Report	53658-Peer-review(s).pdf
Scientific Misconduct Check	53658-Scientific misconduct check.pdf
Scientific Editor Work List	53658-Scientific editor work list.pdf