Publication Name	World Journal of Gastroenterology
Manuscript ID	53658
Country	Japan

Category	Immunology
Manuscript Type	Review
Article Title	Vaccine therapy for dysbiosis-related diseases
Manuscript Source	Invited Manuscript
All Author List	Kosuke Fujimoto and Satoshi Uematsu
Funding Agency and Grant Number	Funding Agency Grant Number Ministry of Education, Culture, Sports, Science, and Technology of Japan (Grant-in-Aid for Early-Career Scientists) 19K17932
Corresponding Author	Satoshi Uematsu, MD, PhD, Professor, Department of Immunology and Genomics, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi, Abeno-ku, Osaka 545-8585, Japan. uematsu.satoshi@med.osaka-cu.ac.jp
Key Words	Dysbiosis; IgA; Microbiome; Mucosal immunity; Pathobiont; Vaccine
Core Tip	How to control intestinal pathogenic bacteria that mediate multifactorial diseases is a major concern worldwide. There are few methods for controlling only intestinal pathogenic bacteria; therefore, we have developed a prime–boost type, next-generation mucosal vaccine, and have used it for control of bacterial intestinal diseases. This vaccine can contribute to prevention of Clostridium ramosum-mediated obesity. Thus, this approach might be useful for protecting against microbe-associated disorders of the intestine.
Citation	Fujimoto K, Uematsu S. Vaccine therapy for dysbiosis-related diseases. World J Gastroenterol 2020; 26(21): 2758-2767

Received	2019-12-27 11:06
Peer-Review Started	2019-12-27 11:12
To Make the First Decision
Return for Revision	2020-02-14 17:43
Revised	2020-03-27 11:36
Second Decision	2020-05-22 09:56
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2020-05-23 01:04
Articles in Press	2020-05-23 01:04
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2020-06-04 07:44

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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