Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	53669
Country	China

Category	Oncology
Manuscript Type	Retrospective Study
Article Title	Association of Helicobacter pylori infection with colorectal polyps and malignancy in China
Manuscript Source	Invited Manuscript
All Author List	Man Wang, Wen-Jie Kong, Jing-Zhan Zhang, Jia-Jie Lu, Wen-Jia Hui, Wei-Dong Liu, Xiao-Jing Kang and Feng Gao
Funding Agency and Grant Number
Corresponding Author	Feng Gao, MD, PhD, Chairman, Professor, Department of Gastroenterology, People’s Hospital of Xinjiang Uygur Autonomous Region, No. 91, Tianchi Road, Tianshan District, Urumqi 830001, Xinjiang Uygur Autonomous Region, China. drxjgf@sina.com
Key Words	Helicobacter pylori; Atrophic gastritis; Intestinal metaplasia; Polyps; Colorectal neoplasms cancer; Gastrointestinal neoplasms
Core Tip	This study investigates the association of gastric H. pylori infection with the risk of colorectal polyps and colorectal cancer (CRC) and suggests that patients with H. pylori infection were 2.19 and 3.05 times more likely to develop colorectal polyps and CRC, respectively, than those without. The prevalence of H. pylori infection was higher in the patient group with multiple polyps and colorectal adenomas than in those with a solitary polyp and non-adenomatous polyps, respectively. Gastric H. pylori infection and H. pylori-associated atrophic gastritis or intestinal metaplasia elevated the risk of colorectal polyps and CRC. Therefore, earlier and frequent colonoscopy would be necessary.
Citation	Wang M, Kong WJ, Zhang JZ, Lu JJ, Hui WJ, Liu WD, Kang XJ, Gao F. Association of Helicobacter pylori infection with colorectal polyps and malignancy in China. World J Gastrointest Oncol 2020; 12(5): 582-591

Received	2019-12-29 15:18
Peer-Review Started	2019-12-29 15:19
To Make the First Decision
Return for Revision	2020-01-19 18:44
Revised	2020-03-13 18:23
Second Decision	2020-03-20 15:40
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2020-03-24 13:09
Articles in Press	2020-03-24 13:09
Publication Fee Transferred
Edit the Manuscript by Language Editor	2020-04-07 01:26
Typeset the Manuscript	2020-04-29 08:03

ISSN	1948-5204 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com