Publication Name	World Journal of Gastroenterology
Manuscript ID	53702
Country	Germany

Category	Infectious Diseases
Manuscript Type	Minireviews
Article Title	Innate immune recognition and modulation in hepatitis D virus infection
Manuscript Source	Invited Manuscript
All Author List	Stephanie Jung, Sebastian Maximilian Altstetter and Ulrike Protzer
Funding Agency and Grant Number	Funding Agency Grant Number German Research Foundation TRR 179
Corresponding Author	Ulrike Protzer, MD, Director, Professor, Institute of Virology, Technical University of Munich/Helmholtz Zentrum München, German Center for Infection Research (DZIF), Munich Partner Site, Trogerstrasse 30, Munich D-81675, Germany. protzer@helmholtz-muenchen.de
Key Words	Hepatitis D virus; Hepatitis B virus; Innate immunity; Pathogen-associated molecular pattern molecules; Immune evasion; Immunosuppression
Core Tip	Hepatitis D virus (HDV) is the only known human satellite virus requiring hepatitis B virus (HBV) coinfection for productive viral release. However, it was recently shown that HDV can be disseminated by viruses other than HBV in experimental setups, so it remains unexplained why HDV chose HBV as a helper virus. As HDV might possibly profit from HBV mediated immunosuppression, we first focus on recent findings on HDV recognition by the innate immune system. Later on, we summarize partially controversial data on immunomodulatory mechanisms of both, HBV and HDV.
Citation	Jung S, Altstetter SM, Protzer U. Innate immune recognition and modulation in hepatitis D virus infection. World J Gastroenterol 2020; 26(21): 2781-2791

Received	2019-12-29 20:11
Peer-Review Started	2019-12-29 20:12
To Make the First Decision
Return for Revision	2020-01-19 00:36
Revised	2020-03-30 13:56
Second Decision	2020-05-22 10:25
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2020-05-23 01:04
Articles in Press	2020-05-23 01:04
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2020-06-03 06:49

ISSN	1007-9327 (print) and 2219-2840 (online)
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