BPG is committed to discovery and dissemination of knowledge
Articles in Press
4/8/2020 4:48:38 AM | Browse: 198 | Download: 350
Publication Name World Journal of Clinical Cases
Manuscript ID 53772
Country/Territory China
Category Gastroenterology & Hepatology
Manuscript Type Review
Article Title Probiotic mixture VSL#3: An overview of basic and clinical studies in chronic diseases
Manuscript Source Invited Manuscript
All Author List Fang-Shu Cheng, Dan Pan, Bing Chang, Min Jiang and Li-Xuan Sang
Funding Agency and Grant Number
Funding Agency Grant Number
Innovative Talent Support Program of the Institution of Higher Learning in Liaoning Province 2018-478
Innovative Talents of Science and Technology Support Program of Young and Middle People of Shenyang RC170446
Corresponding Author Li-Xuan Sang, PhD, Assistant Professor, Chief Doctor, Department of Geriatrics, the First Affiliated Hospital, China Medical University, No. 155, Nanjing North Street, Heping District, Shenyang 110001, Liaoning Province, China. sanglixuan2008@163.com
Key Words VSL#3; Intestinal barrier function; Chronic diseases; Intestinal microbial balance; Cytokines; Therapeutic use
Core Tip The imbalance of intestinal microbiota is one of the important factors in multiple diseases. Probiotics have a benefit on human health as live microorganisms that can positively regulate the intestinal microbial composition. One probiotic mixture, VSL#3, consisting of eight live bacterial strains plays an essential function in preventing and treating digestive systemic and other systemic diseases in animals and humans. There is increasing evidence that VSL#3 works by modulating intestinal barrier function. It is able to improve tight junction protein function and the composition of intestinal microbiota and regulate immune-related cytokine expression. This review seeks to provide an overview of the role of VSL#3 in various kinds of diseases and its potential for clinical use in the future.
Citation Cheng FS, Pan D, Chang B, Jiang M, Sang LX. Probiotic mixture VSL#3: An overview of basic and clinical studies in chronic diseases. World J Clin Cases 2020; 8(8): 1361-1384
Received
2019-12-30 07:05
Peer-Review Started
2019-12-30 07:05
To Make the First Decision
2020-02-23 08:39
Return for Revision
2020-02-26 01:35
Revised
2020-03-27 11:12
Second Decision
2020-04-07 09:55
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-04-08 04:48
Articles in Press
2020-04-08 04:48
Publication Fee Transferred
Edit the Manuscript by Language Editor
2020-04-11 10:04
Typeset the Manuscript
2020-04-21 02:43
ISSN 2307-8960 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com