Category |
Obstetrics & Gynecology |
Manuscript Type |
Minireviews |
Article Title |
Status, challenges, and future prospects of stem cell therapy in pelvic floor disorders
|
Manuscript Source |
Invited Manuscript |
All Author List |
Juan Cheng, Zhi-Wei Zhao, Ji-Rui Wen, Ling Wang, Li-Wei Huang, Yan-Lin Yang, Feng-Nian Zhao, Jing-Yue Xiao, Fei Fang, Jiang Wu and Ya-Li Miao |
Funding Agency and Grant Number |
Funding Agency |
Grant Number |
Foundation of Sichuan Provincial Science and Technology Program |
2019YFH0147 |
Foundation of Sichuan Provincial Science and Technology Program |
2019YFH0158 |
Chengdu Technological Innovation Research and Development Project |
2018-YF05-00195-SN |
West China Second University Hospital Xinya Fund |
kx111 |
1.3.5 Project for Disciplines of Excellence, West China Hospital, Sichuan University |
ZYJC18016 |
|
Corresponding Author |
Ya-Li Miao, MD, PhD, Chief Doctor, Professor, Department of Obstetrics and Gynecology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, West China Second University Hospital, West China Campus, Sichuan University, No. 17 People’s South Road, Chengdu 610041, Sichuan Province, China. miaoyali2006@163.com |
Key Words |
Pelvic floor disorders; Pelvic organ prolapse; Stress urinary incontinence; Mesenchymal stem cells; Stem cell therapy; |
Core Tip |
Recently, various studies using different autologous mesenchymal stem cells (MSCs) have achieved promising results showing that, first, MSCs can undergo transdifferentiation into different cell types of the pelvic floor tissues and improve collagen secretion and neovascularization with induction by a series of cytokines. Second, MSCs can deliver bioactive molecules to the site of injury to promote angiogenesis by enhancing the migration and proliferation of tissue-specific progenitor cells and inhibiting apoptosis, fibrosis through promoting tissue cell proliferation and collagen synthesis, and inhibiting inflammation by recruiting macrophages and leukocytes, thus improving the connective or neuromuscular tissues in pelvic floor disorders. |
Citation |
Cheng J, Zhao ZW, Wen JR, Wang L, Huang LW, Yang YL, Zhao FN, Xiao JY, Fang F, Wu J, Miao YL. Status, challenges, and future prospects of stem cell therapy in pelvic floor disorders. World J Clin Cases 2020; 8(8): 1400-1413 |
ISSN |
2307-8960 (online) |
Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
Website |
http://www.wjgnet.com |