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Publication Name World Journal of Clinical Cases
Manuscript ID 53849
Country/Territory China
Category Obstetrics & Gynecology
Manuscript Type Minireviews
Article Title Status, challenges, and future prospects of stem cell therapy in pelvic floor disorders
Manuscript Source Invited Manuscript
All Author List Juan Cheng, Zhi-Wei Zhao, Ji-Rui Wen, Ling Wang, Li-Wei Huang, Yan-Lin Yang, Feng-Nian Zhao, Jing-Yue Xiao, Fei Fang, Jiang Wu and Ya-Li Miao
Funding Agency and Grant Number
Funding Agency Grant Number
Foundation of Sichuan Provincial Science and Technology Program 2019YFH0147
Foundation of Sichuan Provincial Science and Technology Program 2019YFH0158
Chengdu Technological Innovation Research and Development Project 2018-YF05-00195-SN
West China Second University Hospital Xinya Fund kx111
1.3.5 Project for Disciplines of Excellence, West China Hospital, Sichuan University ZYJC18016
Corresponding Author Ya-Li Miao, MD, PhD, Chief Doctor, Professor, Department of Obstetrics and Gynecology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, West China Second University Hospital, West China Campus, Sichuan University, No. 17 People’s South Road, Chengdu 610041, Sichuan Province, China. miaoyali2006@163.com
Key Words Pelvic floor disorders; Pelvic organ prolapse; Stress urinary incontinence; Mesenchymal stem cells; Stem cell therapy;
Core Tip Recently, various studies using different autologous mesenchymal stem cells (MSCs) have achieved promising results showing that, first, MSCs can undergo transdifferentiation into different cell types of the pelvic floor tissues and improve collagen secretion and neovascularization with induction by a series of cytokines. Second, MSCs can deliver bioactive molecules to the site of injury to promote angiogenesis by enhancing the migration and proliferation of tissue-specific progenitor cells and inhibiting apoptosis, fibrosis through promoting tissue cell proliferation and collagen synthesis, and inhibiting inflammation by recruiting macrophages and leukocytes, thus improving the connective or neuromuscular tissues in pelvic floor disorders.
Citation Cheng J, Zhao ZW, Wen JR, Wang L, Huang LW, Yang YL, Zhao FN, Xiao JY, Fang F, Wu J, Miao YL. Status, challenges, and future prospects of stem cell therapy in pelvic floor disorders. World J Clin Cases 2020; 8(8): 1400-1413
Received
2019-12-31 03:22
Peer-Review Started
2019-12-31 03:23
To Make the First Decision
Return for Revision
2020-02-20 19:54
Revised
2020-03-30 07:37
Second Decision
2020-04-07 09:58
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-04-08 04:46
Articles in Press
2020-04-08 04:46
Publication Fee Transferred
Edit the Manuscript by Language Editor
2020-04-11 10:07
Typeset the Manuscript
2020-04-22 00:39
ISSN 2307-8960 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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