Publication Name	World Journal of Gastrointestinal Pathophysiology
Manuscript ID	53850
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Selective granulocyte and monocyte apheresis in inflammatory bowel disease: Its past, present and future
Manuscript Source	Invited Manuscript
All Author List	Xiu-Li Chen, Jing-Wei Mao and Ying-De Wang
Funding Agency and Grant Number
Corresponding Author	Ying-De Wang, MD, Chief Physician, Professor, Department of Gastroenterology, the First Affiliated Hospital of Dalian Medical University, No. 222, Zhongshan Road, Xigang District, Dalian 116011, Liaoning Province, China. albertwyd@163.com
Key Words	Inflammatory bowel disease; Ulcerative colitis; Crohn’s disease; Granulocyte and monocyte apheresis; Therapy; Efficacy
Core Tip	Conventional therapies for inflammatory bowel disease (IBD) patients including mesalazine, corticosteroids, and immunosuppressants have been used for decades with unsatisfactory outcomes either due to their ineffectiveness or side effects. Although the emerging biologic agents including anti-TNF mono-antibodies have revolutionized IBD treatment, severe opportunistic infections, primary or secondary loss of response and etc. are the major clinical concerns of clinicians and patients as well. In recent years, selective granulocyte and monocyte apheresis, as a therapeutic option for IBD patients, have been used in Japan, Europe, China and elsewhere for its advantages of satisfactory efficacy, and particularly high safety profile. It is hopeful that granulocyte and monocyte apheresis therapy will become an important, and yet promising therapeutic option for patients with IBD.
Citation	Chen XL, Mao JW, Wang YD. Selective granulocyte and monocyte apheresis in inflammatory bowel disease: Its past, present and future. World J Gastrointest Pathophysiol 2020; 11(3): 43-56

Received	2019-12-31 07:20
Peer-Review Started	2019-12-31 07:32
To Make the First Decision	2020-03-02 04:03
Return for Revision	2020-03-03 00:09
Revised	2020-03-05 03:54
Second Decision	2020-04-08 13:58
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2020-04-09 00:22
Articles in Press	2020-04-09 00:22
Publication Fee Transferred
Edit the Manuscript by Language Editor	2020-04-14 01:27
Typeset the Manuscript	2020-05-11 01:07

ISSN	2150-5330 (online)
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